N-acetylneuraminate epimerase

N-acetylneuraminate epimerase (EC 5.1.3.24, sialic acid epimerase, N-acetylneuraminate mutarotase, YjhT) is an enzyme with systematic name N-acetyl-alpha-neuraminate 2-epimerase.^[1] This enzyme catalyses the following chemical reaction

N-acetyl-alpha-neuraminate

\rightleftharpoons

N-acetyl-beta-neuraminate

Sialoglycoconjugates present in vertebrates are linked exclusively by alpha-linkages.

References

↑ Severi, E., Müller, A., Potts, J.R., Leech, A., Williamson, D., Wilson, K.S. and Thomas, G.H. (2008). "Sialic acid mutarotation is catalyzed by the Escherichia coli β-propeller protein YjhT". J. Biol. Chem. 283: 4841–4849. doi:10.1074/jbc.M707822200. PMID 18063573.

External links

N-acetylneuraminate epimerase at the US National Library of Medicine Medical Subject Headings (MeSH)

Isomerases: Epimerase and racemases (EC 5.1)

5.1.1: Amino acids	Amino-acid racemase: Phenylalanine racemase (ATP-hydrolysing) Serine racemase

5.1.2: Hydroxy acids	Mandelate racemase

5.1.3: Carbohydrates	UDP-glucose 4-epimerase

5.1.99: Other	Methylmalonyl CoA epimerase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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