N-acylglucosamine-6-phosphate 2-epimerase

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is N-acyl-D-glucosamine-6-phosphate 2-epimerase. Other names in common use include acylglucosamine-6-phosphate 2-epimerase, and acylglucosamine phosphate 2-epimerase. This enzyme participates in aminosugars metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1Y0E and 1YXY.

References

Ghosh S and Roseman S (1965). "The sialic acids. IV. N-Acyl-D-glucosamine 6-phosphate 2-epimerase". J. Biol. Chem. 240: 1525–1530. PMID 14285487.

Isomerases: Epimerase and racemases (EC 5.1)

5.1.1: Amino acids	Amino-acid racemase: Phenylalanine racemase (ATP-hydrolysing) Serine racemase

5.1.2: Hydroxy acids	Mandelate racemase

5.1.3: Carbohydrates	UDP-glucose 4-epimerase

5.1.99: Other	Methylmalonyl CoA epimerase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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