N-carbamoylsarcosine amidase

N-carbamoylsarcosine amidase
Identifiers
EC number	3.5.1.59
CAS number	92767-52-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a N-carbamoylsarcosine amidase (EC 3.5.1.59) is an enzyme that catalyzes the chemical reaction

N-carbamoylsarcosine + H₂O $\rightleftharpoons$ sarcosine + CO₂ + NH₃

Thus, the two substrates of this enzyme are N-carbamoylsarcosine and H₂O, whereas its 3 products are sarcosine, CO₂, and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-carbamoylsarcosine amidohydrolase. This enzyme is also called carbamoylsarcosine amidase. This enzyme participates in arginine and proline metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1NBA.

References

• Deeg R, Roeder A, Siedel J, Gauhl H and Ziegenhorn J (1984). "Process and reagent for the determination of N-carbamoylsarcosine with the use of a new enzyme". Chem. Abstr. 101: 18751.