N-methyl-2-oxoglutaramate hydrolase

N-methyl-2-oxoglutaramate hydrolase
Identifiers
EC number	3.5.1.36
CAS number	9073-53-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a N-methyl-2-oxoglutaramate hydrolase (EC 3.5.1.36) is an enzyme that catalyzes the chemical reaction

N-methyl-2-oxoglutaramate + H₂O $\rightleftharpoons$ 2-oxoglutarate + methylamine

Thus, the two substrates of this enzyme are N-methyl-2-oxoglutaramate and H₂O, whereas its two products are 2-oxoglutarate and methylamine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-methyl-2-oxoglutaramate methylamidohydrolase. This enzyme is also called 5-hydroxy-N-methylpyroglutamate synthase.

References

• Hersh LB (1970). "5-hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action". J. Biol. Chem. 245 (14): 3526–35. PMID 5470822.
• Hersh LB, Tsai L, Stadtman ER (1969). "The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid". J. Biol. Chem. 244 (17): 4677–83. PMID 5808511.