N4-(beta-N-acetylglucosaminyl)-L-asparaginase

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N4-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26, aspartylglucosylamine deaspartylase, aspartylglucosylaminase, aspartylglucosaminidase, aspartylglycosylamine amidohydrolase, N-aspartyl-beta-glucosaminidase, glucosylamidase, beta-aspartylglucosylamine amidohydrolase, 4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase) is an enzyme with systematic name N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

N⁴-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H₂O

\rightleftharpoons

N-acetyl-beta-D-glucosaminylamine + L-aspartate

This enzyme acts only on asparagine-oligosaccharides containing one amino acid.

References

↑ Kohno, M. and Yamashina, I. (1972). "Purification and properties of 4-L-aspartylglycosylamine amidohydrolase from hog kidney". Biochim. Biophys. Acta 258: 600–617. doi:10.1016/0005-2744(72)90252-5. PMID 5010303.
↑ Mahadevan, S. and Tappel, A.L. (1967). "β-Aspartylglucosylamine amido hydrolase of rat liver and kidney". J. Biol. Chem. 242: 4568–4576. PMID 6061403.
↑ Tarentino, A.L. and Maley, F. (1969). "The purification and properties of a β-aspartyl N-acetylglucosylamine amidohydrolase from hen oviduct". Arch. Biochem. Biophys. 130: 295–303. doi:10.1016/0003-9861(69)90036-8. PMID 5778645.

External links

N4-(beta-N-acetylglucosaminyl)-L-asparaginase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolases: carbon-nitrogen non-peptide (EC 3.5)

3.5.1: Linear amides / Amidohydrolases	Asparaginase Glutaminase Urease Biotinidase Aspartoacylase Ceramidase Aspartylglucosaminidase Fatty acid amide hydrolase Histone deacetylase Sirtuin

3.5.2: Cyclic amides/ Amidohydrolases	Barbiturase Beta-lactamase

3.5.3: Linear amidines/ Ureohydrolases	Arginase Agmatinase Protein-arginine deiminase

3.5.4: Cyclic amidines/ Aminohydrolases	Guanine deaminase Adenosine deaminase AMP deaminase Inosine monophosphate synthase DCMP deaminase GTP cyclohydrolase I Cytidine deaminase AICDA Activation-induced cytidine deaminase

3.5.5: Nitriles/ Aminohydrolases	Nitrilase

3.5.99: Other	Riboflavinase Thiaminase II

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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N4-(beta-N-acetylglucosaminyl)-L-asparaginase

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References

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