NAD(P)H-hydrate epimerase

NAD(P)H-hydrate epimerase
Identifiers
EC number	5.1.99.6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

NAD(P)H-hydrate epimerase (EC 5.1.99.6, NAD(P)HX epimerase) is an enzyme with systematic name (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide 6-epimerase.^[1] This enzyme catalyses the following chemical reaction

(1) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide $\rightleftharpoons$ (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide

(2) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate $\rightleftharpoons$ (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate

The enzyme can use either (R)-NADH-hydrate or (R)-NADPH-hydrate as a substrate.

References

1. Marbaix, A.Y., Noel, G., Detroux, A.M., Vertommen, D., Van Schaftingen, E. and Linster, C.L. (2011). "Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair". J. Biol. Chem. 286: 41246–41252. doi:10.1074/jbc.c111.310847. PMID 21994945.

External links

• NAD(P)H-hydrate epimerase at the US National Library of Medicine Medical Subject Headings (MeSH)