Neuregulin 2

Neuregulin 2
Identifiers
Symbols	NRG2 ; DON1; HRG2; NTAK
External IDs	OMIM: 603818 HomoloGene: 75024 GeneCards: NRG2 Gene
Gene ontology Molecular function • receptor binding • growth factor activity Cellular component • extracellular region • extracellular space • intracellular • plasma membrane • integral component of membrane Biological process • signal transduction • epidermal growth factor receptor signaling pathway • fibroblast growth factor receptor signaling pathway • embryo development • intracellular signal transduction • Fc-epsilon receptor signaling pathway • innate immune response • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • organ development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9542	100042150
Ensembl	ENSG00000158458	ENSMUSG00000060275
UniProt	O14511	P56974
RefSeq (mRNA)	NM_001184935	NM_001167891
RefSeq (protein)	NP_001171864	NP_001161363
Location (UCSC)	Chr 5: 139.85 – 140.04 Mb	Chr 18: 36.02 – 36.2 Mb
PubMed search

Neuregulin 2, also known as NRG2, is a protein which in humans is encoded by the NRG2 gene.^[1][2][3]

Function

Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcripts encoding distinct isoforms have been described.^[1]

References

1. "Entrez Gene: NRG2 neuregulin 2".
2. Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ (May 1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature 387 (6632): 509–12. doi:10.1038/387509a0. PMID 9168114.
3. Carraway KL, Weber JL, Unger MJ, Ledesma J, Yu N, Gassmann M, Lai C (May 1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases". Nature 387 (6632): 512–6. doi:10.1038/387512a0. PMID 9168115.

Further reading

• Chang H, Riese DJ, Gilbert W, et al. (1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature 387 (6632): 509–12. doi:10.1038/387509a0. PMID 9168114.
• Carraway KL, Weber JL, Unger MJ, et al. (1997). "Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases". Nature 387 (6632): 512–6. doi:10.1038/387512a0. PMID 9168115.
• Busfield SJ, Michnick DA, Chickering TW, et al. (1997). "Characterization of a neuregulin-related gene, Don-1, that is highly expressed in restricted regions of the cerebellum and hippocampus". Mol. Cell. Biol. 17 (7): 4007–14. PMC: 232253. PMID 9199335.
• Higashiyama S, Horikawa M, Yamada K, et al. (1998). "A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4". J. Biochem. 122 (3): 675–80. doi:10.1093/oxfordjournals.jbchem.a021806. PMID 9348101.
• Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method". Genomics 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.
• Ring HZ, Chang H, Guilbot A, et al. (1999). "The human neuregulin-2 (NRG2) gene: cloning, mapping and evaluation as a candidate for the autosomal recessive form of Charcot-Marie-Tooth disease linked to 5q". Hum. Genet. 104 (4): 326–32. doi:10.1007/s004390050961. PMID 10369162.
• Yamada K, Ichino N, Nishii K, et al. (2000). "Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA". Gene 255 (1): 15–24. doi:10.1016/S0378-1119(00)00309-7. PMID 10974560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC: 139241. PMID 12477932.
• Nakano N, Higashiyama S, Ohmoto H, et al. (2004). "The N-terminal region of NTAK/neuregulin-2 isoforms has an inhibitory activity on angiogenesis". J. Biol. Chem. 279 (12): 11465–70. doi:10.1074/jbc.M311045200. PMID 14722120.
• Ponomareva ON, Ma H, Dakour R, et al. (2005). "Stimulation of acetylcholine receptor transcription by neuregulin-2 requires an N-box response element and is regulated by alternative splicing". Neuroscience 134 (2): 495–503. doi:10.1016/j.neuroscience.2005.04.028. PMID 15961242.
• Fan BJ, Ko WC, Wang DY, et al. (2007). "Fine mapping of new glaucoma locus GLC1M and exclusion of neuregulin 2 as the causative gene". Mol. Vis. 13: 779–84. PMC: 2768763. PMID 17563728.