Nucleoporin 160

Nucleoporin 160kDa
Identifiers
Symbols	NUP160 ; DKFZp686M14102; MGC150678; MGC150679
External IDs	OMIM: 607614 MGI: 1926227 HomoloGene: 32509 GeneCards: NUP160 Gene
Gene ontology Molecular function • nucleocytoplasmic transporter activity • protein binding Cellular component • kinetochore • nuclear envelope • nuclear pore • cytosol • nuclear pore outer ring Biological process • mitotic cell cycle • carbohydrate metabolic process • mRNA export from nucleus • mitotic nuclear envelope disassembly • small GTPase mediated signal transduction • hexose transport • gene expression • regulation of glucose transport • protein transport • glucose transport • viral process • protein sumoylation • viral life cycle • viral transcription • cytokine-mediated signaling pathway • cellular response to heat • post-translational protein modification • cellular protein metabolic process • small molecule metabolic process • transmembrane transport • regulation of cellular response to heat Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23279	59015
Ensembl	ENSG00000030066	ENSMUSG00000051329
UniProt	Q12769	Q9Z0W3
RefSeq (mRNA)	NM_015231	NM_021512
RefSeq (protein)	NP_056046	NP_067487
Location (UCSC)	Chr 11: 47.78 – 47.85 Mb	Chr 2: 90.68 – 90.74 Mb
PubMed search

Nucleoporin 160 (Nup160) is a protein that in humans is encoded by the NUP160 gene.^[1][2]

NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore complex, which mediates nucleoplasmic transport.[supplied by OMIM]^[2]

References

1. Vasu S, Shah S, Orjalo A, Park M, Fischer WH, Forbes DJ (Oct 2001). "Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export". J Cell Biol 155 (3): 339–54. doi:10.1083/jcb.200108007. PMC 2150853. PMID 11684705.
2. "Entrez Gene: NUP160 nucleoporin 160kDa".

Further reading

• Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
• Belgareh N, Rabut G, Baï SW, et al. (2001). "An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells.". J. Cell Biol. 154 (6): 1147–60. doi:10.1083/jcb.200101081. PMC 2150808. PMID 11564755.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Loïodice I, Alves A, Rabut G, et al. (2005). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis.". Mol. Biol. Cell 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057.
• Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle.". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Orjalo AV, Arnaoutov A, Shen Z, et al. (2006). "The Nup107-160 nucleoporin complex is required for correct bipolar spindle assembly.". Mol. Biol. Cell 17 (9): 3806–18. doi:10.1091/mbc.E05-11-1061. PMC 1593160. PMID 16807356.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Glavy JS, Krutchinsky AN, Cristea IM, et al. (2007). "Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex.". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 3811–6. doi:10.1073/pnas.0700058104. PMC 1820666. PMID 17360435.
• Zuccolo M, Alves A, Galy V, et al. (2007). "The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions.". EMBO J. 26 (7): 1853–64. doi:10.1038/sj.emboj.7601642. PMC 1847668. PMID 17363900.