Nucleoporin 205

Nucleoporin 205kDa
Identifiers
Symbols	NUP205 ; C7orf14
External IDs	OMIM: 614352 MGI: 2141625 HomoloGene: 45971 GeneCards: NUP205 Gene
Gene ontology Molecular function • protein binding • structural constituent of nuclear pore Cellular component • nuclear envelope • nuclear pore • nucleoplasm • cytoplasm • membrane • nuclear membrane • nuclear periphery Biological process • protein import into nucleus, docking • mitotic cell cycle • carbohydrate metabolic process • nucleocytoplasmic transport • mitotic nuclear envelope disassembly • hexose transport • gene expression • regulation of glucose transport • glucose transport • viral process • protein sumoylation • viral life cycle • viral transcription • cytokine-mediated signaling pathway • cellular response to heat • post-translational protein modification • cellular protein metabolic process • small molecule metabolic process • mRNA transport • nuclear pore complex assembly • transmembrane transport • regulation of cellular response to heat Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23165	70699
Ensembl	ENSG00000155561	ENSMUSG00000038759
UniProt	Q92621	E9Q880
RefSeq (mRNA)	NM_015135	NM_027513
RefSeq (protein)	NP_055950	NP_081789
Location (UCSC)	Chr 7: 135.56 – 135.65 Mb	Chr 6: 35.18 – 35.25 Mb
PubMed search

Nucleoporin 205 (Nup205) is a protein that in humans is encoded by the NUP205 gene.^[1][2][3]

Function

Transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPC's are composed of subcomplexes, and NUP205 is part of one such subcomplex.^[1]

References

1. "Entrez Gene: NUP205 nucleoporin 205kDa".
2. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
3. Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E (October 1997). "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly". Mol. Biol. Cell 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664. PMID 9348540.

Further reading

• Hawryluk-Gara LA, Shibuya EK, Wozniak RW (2005). "Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex". Mol. Biol. Cell 16 (5): 2382–94. doi:10.1091/mbc.E04-10-0857. PMC 1087243. PMID 15703211.
• Grandi P, Dang T, Pané N, Shevchenko A, Mann M, Forbes D, Hurt E (1997). "Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly". Mol. Biol. Cell 8 (10): 2017–38. doi:10.1091/mbc.8.10.2017. PMC 25664. PMID 9348540.
• Le Rouzic E, Mousnier A, Rustum C, Stutz F, Hallberg E, Dargemont C, Benichou S (2002). "Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1". J. Biol. Chem. 277 (47): 45091–8. doi:10.1074/jbc.M207439200. PMID 12228227.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Hase ME, Cordes VC (2003). "Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex". Mol. Biol. Cell 14 (5): 1923–40. doi:10.1091/mbc.E02-09-0620. PMC 165087. PMID 12802065.
• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Sowa ME, Bennett EJ, Gygi SP, Harper JW (2009). "Defining the human deubiquitinating enzyme interaction landscape". Cell 138 (2): 389–403. doi:10.1016/j.cell.2009.04.042. PMC 2716422. PMID 19615732.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.