Nucleoporin 35

Nucleoporin 35kDa
PDB rendering based on 1wwh.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4LIR​
Identifiers
Symbols	NUP35 ; MP-44; MP44; NP44; NUP53
External IDs	OMIM: 608140 MGI: 1916732 HomoloGene: 44517 GeneCards: NUP35 Gene
Gene ontology Molecular function • protein binding Cellular component • nuclear envelope • nuclear pore • nuclear lamina • nucleoplasm • plasma membrane • nuclear membrane • intracellular membrane-bounded organelle • intermediate filament cytoskeleton Biological process • mitotic cell cycle • carbohydrate metabolic process • mitotic nuclear envelope disassembly • hexose transport • gene expression • regulation of glucose transport • protein transport • glucose transport • viral process • protein sumoylation • viral life cycle • viral transcription • cytokine-mediated signaling pathway • cellular response to heat • post-translational protein modification • cellular protein metabolic process • small molecule metabolic process • mRNA transport • transmembrane transport • regulation of cellular response to heat Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	129401	69482
Ensembl	ENSG00000163002	ENSMUSG00000026999
UniProt	Q8NFH5	Q8R4R6
RefSeq (mRNA)	NM_001008544	NM_001190179
RefSeq (protein)	NP_001274513	NP_001177108
Location (UCSC)	Chr 2: 183.12 – 183.16 Mb	Chr 2: 80.62 – 80.66 Mb
PubMed search

Nucleoporin 35 (Nup35) is a protein that in humans is encoded by the NUP35 gene.^[1]

Background

This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is part of the nuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC.^[1]

References

1. "Entrez Gene: NUP35 nucleoporin 35kDa".

Further reading

• Rodenas E, Klerkx EP, Ayuso C, Audhya A, Askjaer P. (2009). "Early embryonic requirement for nucleoporin Nup35/NPP-19 in nuclear assembly.". Developmental Biology 327 (2): 399–409. doi:10.1016/j.ydbio.2008.12.024. PMID 19146848.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Mansfeld J, Güttinger S, Hawryluk-Gara LA, et al. (2006). "The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells.". Mol. Cell 22 (1): 93–103. doi:10.1016/j.molcel.2006.02.015. PMID 16600873.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Hawryluk-Gara LA, Shibuya EK, Wozniak RW (2005). "Vertebrate Nup53 Interacts with the Nuclear Lamina and Is Required for the Assembly of a Nup93-containing Complex". Mol. Biol. Cell 16 (5): 2382–94. doi:10.1091/mbc.E04-10-0857. PMC 1087243. PMID 15703211.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cronshaw JM, Krutchinsky AN, Zhang W, et al. (2002). "Proteomic analysis of the mammalian nuclear pore complex". J. Cell Biol. 158 (5): 915–27. doi:10.1083/jcb.200206106. PMC 2173148. PMID 12196509.