Nucleoporin 43

Nucleoporin 43kDa
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4I79​
Identifiers
Symbols	NUP43 ; bA350J20.1; p42
External IDs	OMIM: 608141 MGI: 1917162 HomoloGene: 11639 GeneCards: NUP43 Gene
Gene ontology Molecular function • protein binding Cellular component • kinetochore • condensed chromosome kinetochore • nuclear envelope • cytosol • nuclear pore outer ring Biological process • mitotic cell cycle • carbohydrate metabolic process • chromosome segregation • mitotic nuclear division • mitotic nuclear envelope disassembly • small GTPase mediated signal transduction • hexose transport • gene expression • regulation of glucose transport • protein transport • glucose transport • viral process • protein sumoylation • viral life cycle • viral transcription • cytokine-mediated signaling pathway • cellular response to heat • post-translational protein modification • cellular protein metabolic process • small molecule metabolic process • mRNA transport • cell division • transmembrane transport • regulation of cellular response to heat Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	348995	69912
Ensembl	ENSG00000120253	ENSMUSG00000040034
UniProt	Q8NFH3	P59235
RefSeq (mRNA)	NM_024647	NM_145706
RefSeq (protein)	NP_942590	NP_663752
Location (UCSC)	Chr 6: 149.72 – 149.75 Mb	Chr 10: 7.67 – 7.68 Mb
PubMed search

Nucleoporin 43 (Nup43) is a protein that in humans is encoded by the NUP43 gene.^[1][2]

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004).[supplied by OMIM]^[2]

References

1. Cronshaw JM, Krutchinsky AN, Zhang W, Chait BT, Matunis MJ (Sep 2002). "Proteomic analysis of the mammalian nuclear pore complex". J Cell Biol 158 (5): 915–27. doi:10.1083/jcb.200206106. PMC 2173148. PMID 12196509.
2. "Entrez Gene: NUP43 nucleoporin 43kDa".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Loïodice I, Alves A, Rabut G, et al. (2005). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis.". Mol. Biol. Cell 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.