Pegfilgrastim

Pegfilgrastim
Systematic (IUPAC) name
N-(3-Hydroxypropyl)Methionylcolony-stimulating Factor (human), 1-Ether with .Alpha.-Methyl-.Omega.-Hydroxypoly(Oxyethylene)
Clinical data
Trade names originally Neulasta, other brand names worldwide[1]
AHFS/Drugs.com monograph
MedlinePlus a607058
Pregnancy
category
  • US: C (Risk not ruled out)
Legal status
Legal status
Pharmacokinetic data
Biological half-life 15–80 hrs
Identifiers
CAS Number 208265-92-3 YesY
ATC code L03AA13 (WHO)
IUPHAR/BPS 6969
DrugBank DB00019 YesY
ChemSpider none
UNII 3A58010674 YesY
KEGG D06889 YesY
ChEMBL CHEMBL1201568 N
Chemical data
Formula C845H1343N223O243S9 + PEG
Molar mass 39,000 g/mol
 NYesY (what is this?)  (verify)

Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (GCSF) analog filgrastim. It serves to stimulate the level of white blood cells (neutrophils).[2]

Pegfilgrastim treatment can be used to stimulate bone marrow to produce more neutrophils to fight infection in patients undergoing chemotherapy.[3]

Pegfilgrastim has a human half-life of 15 to 80 hours, much longer than the parent filgrastim (3–4 hours).[4][3]

See also

References

  1. Drugs.com International brand names for pegfilgrastim Page accessed April 1, 2016
  2. Walsh, G, Spada, S. "Epogen/Procrit" in: Directory of approved biopharmaceutical products. CRC Press, 2005, pp. 136–137.
  3. 1 2 Drugs.com: Pegfilgrastim
  4. Ho, R.J.Y., Gibaldi, M. Biotechnology and biopharmaceuticals: transforming proteins and genes into drugs Wiley-IEEE, 2003, p. 139, 158.

External links


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