Thymosin α1

Prothymosin, alpha
NMR structure of thymosin alpha-1. PDB 2l9i [1]
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2L9I​, 2MNQ​
Identifiers
Symbols	PTMA ; TMSA
External IDs	OMIM: 188390 MGI: 97803 HomoloGene: 136511 GeneCards: PTMA Gene
Gene ontology Molecular function • protein binding Cellular component • nucleus • nucleoplasm • cytoplasm • extracellular exosome Biological process • transcription, DNA-templated Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5757	100504173
Ensembl	ENSG00000187514	ENSMUSG00000026238
UniProt	P06454	P26350
RefSeq (mRNA)	NM_001099285	n/a
RefSeq (protein)	NP_001092755	n/a
Location (UCSC)	Chr 2: 231.71 – 231.71 Mb	Chr 1: 86.53 – 86.53 Mb
PubMed search

Thymosin α₁ is a peptide fragment derived from prothymosin alpha, a protein that in humans is encoded by the PTMA gene.^[2]

Function

Thymosin α₁ is believed to be a major component of Thymosin Fraction 5 responsible for the activity of that preparation in restoring immune function in animals lacking thymus glands. It was the first of the peptides from Thymosin Fraction 5 to be completely sequenced and synthesized. Unlike β thymosins, to which it is genetically and chemically unrelated, thymosin α₁ is produced as a 28-amino acid fragment, from a longer, 113-amino acid precursor, prothymosin α.^[3] It has been found to enhance cell-mediated immunity in humans as well as experimental animals.^[4]

Therapeutic application

Thymosin α₁ is now approved in 35 under developed or developing countries for the treatment of Hepatitis B and C, and it is also used to boost the immune response in the treatment of other diseases.^[5][6]

See also

• Thymosins

References

1. Elizondo-Riojas, M. A.; Chamow, S. M.; Tuthill, C. W.; Gorenstein, D. G.; Volk, D. E. (2011). "NMR structure of human thymosin alpha-1". Biochemical and Biophysical Research Communications 416 (3–4): 356–361. doi:10.1016/j.bbrc.2011.11.041. PMC 3419376. PMID 22115779.
2. Manrow RE, Leone A, Krug MS, Eschenfeldt WH, Berger SL (Jul 1992). "The human prothymosin alpha gene family contains several processed pseudogenes lacking deleterious lesions". Genomics 13 (2): 319–31. doi:10.1016/0888-7543(92)90248-Q. PMID 1612591.
3. Garaci E (September 2007). "Thymosin alpha1: a historical overview". Ann. N. Y. Acad. Sci. 1112: 14–20. doi:10.1196/annals.1415.039. PMID 17567941.
4. Wara DW, Goldstein AL, Doyle NE, Ammann AJ (January 1975). "Thymosin activity in patients with cellular immunodeficiency". N. Engl. J. Med. 292 (2): 70–4. doi:10.1056/NEJM197501092920204. PMID 1078552.
5. Garaci E, Favalli C, Pica F, et al. (September 2007). "Thymosin alpha 1: from bench to bedside". Ann. N. Y. Acad. Sci. 1112: 225–34. doi:10.1196/annals.1415.044. PMID 17600290.
6. Goldstein AL, Goldstein AL (May 2009). "From lab to bedside: emerging clinical applications of thymosin alpha 1". Expert Opin Biol Ther 9 (5): 593–608. doi:10.1517/14712590902911412. PMID 19392576.

Further reading

• Martini PG, Katzenellenbogen BS (2003). "Modulation of estrogen receptor activity by selective coregulators.". J. Steroid Biochem. Mol. Biol. 85 (2-5): 117–22. doi:10.1016/S0960-0760(03)00207-3. PMID 12943695.
• Barcia MG, Castro JM, Jullien CD, et al. (1992). "Prothymosin alpha is phosphorylated by casein kinase-2.". FEBS Lett. 312 (2-3): 152–6. doi:10.1016/0014-5793(92)80924-6. PMID 1426245.
• Baxevanis CN, Thanos D, Reclos GJ, et al. (1992). "Prothymosin alpha enhances human and murine MHC class II surface antigen expression and messenger RNA accumulation.". J. Immunol. 148 (7): 1979–84. PMID 1545115.
• Gallego R, Rosón E, García-Caballero T, et al. (1992). "Prothymosin alpha expression in lymph nodes and tonsils: an optical and ultrastructural study.". Acta Anat (Basel) 143 (3): 219–22. doi:10.1159/000147251. PMID 1632187.
• Cordero OJ, Sarandeses CS, López JL, et al. (1992). "Prothymosin alpha enhances interleukin 2 receptor expression in normal human T-lymphocytes.". Int. J. Immunopharmacol. 13 (8): 1059–65. doi:10.1016/0192-0561(91)90156-2. PMID 1814846.
• Watts JD, Cary PD, Sautiere P, Crane-Robinson C (1990). "Thymosins: both nuclear and cytoplasmic proteins.". Eur. J. Biochem. 192 (3): 643–51. doi:10.1111/j.1432-1033.1990.tb19271.x. PMID 2209614.
• Eschenfeldt WH, Manrow RE, Krug MS, Berger SL (1989). "Isolation and partial sequencing of the human prothymosin alpha gene family. Evidence against export of the gene products.". J. Biol. Chem. 264 (13): 7546–55. PMID 2708378.
• Gómez-Márquez J, Segade F, Dosil M, et al. (1989). "The expression of prothymosin alpha gene in T lymphocytes and leukemic lymphoid cells is tied to lymphocyte proliferation.". J. Biol. Chem. 264 (15): 8451–4. PMID 2785990.
• Goodall GJ, Dominguez F, Horecker BL (1987). "Molecular cloning of cDNA for human prothymosin alpha.". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 8926–8. doi:10.1073/pnas.83.23.8926. PMC 387046. PMID 3466166.
• Eschenfeldt WH, Berger SL (1987). "The human prothymosin alpha gene is polymorphic and induced upon growth stimulation: evidence using a cloned cDNA.". Proc. Natl. Acad. Sci. U.S.A. 83 (24): 9403–7. doi:10.1073/pnas.83.24.9403. PMC 387146. PMID 3467312.
• Panneerselvam C, Haritos AA, Caldarella J, Horecker BL (1987). "Prothymosin alpha in human blood.". Proc. Natl. Acad. Sci. U.S.A. 84 (13): 4465–9. doi:10.1073/pnas.84.13.4465. PMC 305110. PMID 3474615.
• Pan LX, Haritos AA, Wideman J, et al. (1986). "Human prothymosin alpha: amino acid sequence and immunologic properties.". Arch. Biochem. Biophys. 250 (1): 197–201. doi:10.1016/0003-9861(86)90717-4. PMID 3532956.
• Kubota S, Adachi Y, Copeland TD, Oroszlan S (1995). "Binding of human prothymosin alpha to the leucine-motif/activation domains of HTLV-I Rex and HIV-1 Rev.". Eur. J. Biochem. 233 (1): 48–54. doi:10.1111/j.1432-1033.1995.048_1.x. PMID 7588773.
• Garcia-Caballero T, Dominguez F, Roson E, et al. (1994). "Distribution of prothymosin alpha in rat and human adrenal cortex.". Anat. Rec. 239 (1): 88–94. doi:10.1002/ar.1092390110. PMID 7913591.
• Szabo P, Panneerselvam C, Clinton M, et al. (1993). "Prothymosin alpha gene in humans: organization of its promoter region and localization to chromosome 2.". Hum. Genet. 90 (6): 629–34. doi:10.1007/BF00202480. PMID 7916742.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Tsitsiloni OE, Stiakakis J, Koutselinis A, et al. (1993). "Expression of alpha-thymosins in human tissues in normal and abnormal growth.". Proc. Natl. Acad. Sci. U.S.A. 90 (20): 9504–7. doi:10.1073/pnas.90.20.9504. PMC 47597. PMID 8415730.
• Sburlati AR, De La Rosa A, Batey DW, et al. (1993). "Phosphorylation of human and bovine prothymosin alpha in vivo.". Biochemistry 32 (17): 4587–96. doi:10.1021/bi00068a015. PMID 8485135.
• Rubtsov IuP, Vartapetian AB (1996). "[New intronless members of human prothymosin alpha genes]". Mol. Biol. (Mosk.) 29 (6): 1320–5. PMID 8592501.