Nicotinamide-nucleotide amidase
In enzymology, a nicotinamide-nucleotide amidase (EC 3.5.1.42) is an enzyme that catalyzes the chemical reaction
- beta-nicotinamide D-ribonucleotide + H2O
beta-nicotinate D-ribonucleotide + NH3
Thus, the two substrates of this enzyme are beta-nicotinamide D-ribonucleotide and H2O, whereas its two products are beta-nicotinate D-ribonucleotide and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is nicotinamide-D-ribonucleotide amidohydrolase. Other names in common use include NMN deamidase, nicotinamide mononucleotide deamidase, and nicotinamide mononucleotide amidohydrolase. This enzyme participates in nicotinate and nicotinamide metabolism.
References
- Imai T. "Purification and properties of nicotinamide mononucleotide amidohydrolase from Azotobacter vinelandii". J. (Tokyo). Biochem. (1): 139–53. PMID 4144084.
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