Nitric-oxide reductase

nitric oxide reductase
Identifiers
EC number	1.7.2.5
CAS number	37256-43-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a nitric-oxide reductase (EC 1.7.2.5) is an enzyme that catalyzes the chemical reaction

2 nitric oxide + electron donor $\rightleftharpoons$ nitrous oxide + oxidized electron donor + H₂O

The 2 substrates of this enzyme are nitric oxide and electron donor, whereas its three products are nitrous oxide, oxidized electron donor/acceptor, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with other acceptors. The systematic name of this enzyme class is nitrous-oxide:acceptor oxidoreductase (NO-forming). Other names in common use include nitrogen oxide reductase, and nitrous-oxide:(acceptor) oxidoreductase (NO-forming). This enzyme participates in nitrogen metabolism and in the microbial defense against nitric oxide toxicity.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1EHE, 1F24, 1F25, 1F26, 1JFB, 1JFC, 1ULW, and 1XQD.

References

• Heiss B, Frunzke K, Zumft WG (1989). "Formation of the N-N bond from nitric oxide by a membrane-bound cytochrome bc complex of nitrate-respiring (denitrifying) Pseudomonas stutzeri". J. Bacteriol. 171 (6): 3288–97. PMC 210048. PMID 2542222.
• Gardner AM, Helmick RA, Gardner PR (2002). "Flavorubredoxin, an inducible catalyst for nitric oxide reduction and detoxification in Escherichia coli". J. Biol. Chem. 277 (10): 8172–77. doi:10.1074/jbc.M110471200. PMID 11751865.