Nitric oxide reductase (NAD(P), nitrous oxide-forming)

Nitric oxide reductase (NAD(P), nitrous oxide-forming)
Identifiers
EC number	1.7.1.14
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Nitric oxide reductase (NAD(P), nitrous oxide-forming) (EC 1.7.1.14, fungal nitric oxide reductase, cytochrome P450nor, NOR (ambiguous)) is an enzyme with systematic name nitrous oxide:NAD(P) oxidoreductase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

N₂O + NAD(P)⁺ + H2O $\rightleftharpoons$ 2 NO + NAD(P)H + H⁺

This enzyme is heme-thiolate protein (P450).

References

1. Shoun, H. and Tanimoto, T. (1991). "Denitrification by the fungus Fusarium oxysporum and involvement of cytochrome P-450 in the respiratory nitrite reduction". J. Biol. Chem. 266 (17): 11078–11082. PMID 2040619.
2. Shiro, Y., Fujii, M., Iizuka, T., Adachi, S., Tsukamoto, K., Nakahara, K. and Shoun, H. (1995). "Spectroscopic and kinetic studies on reaction of cytochrome P₄₅₀nor with nitric oxide. Implication for its nitric oxide reduction mechanism". J. Biol. Chem. 270 (4): 1617–1623. PMID 7829493.
3. Zhang, L., Kudo, T., Takaya, N. and Shoun, H. (2002). "The B′ helix determines cytochrome P₄₅₀nor specificity for the electron donors NADH and NADPH". J. Biol. Chem. 277: 33842–33847. doi:10.1074/jbc.M203923200. PMID 12105197.
4. Oshima, R., Fushinobu, S., Su, F., Zhang, L., Takaya, N. and Shoun, H. (2004). "Structural evidence for direct hydride transfer from NADH to cytochrome P₄₅₀nor". J. Mol. Biol. 342: 207–217. doi:10.1016/j.jmb.2004.07.009. PMID 15313618.

External links

• Nitric oxide reductase (NAD(P), nitrous oxide-forming) at the US National Library of Medicine Medical Subject Headings (MeSH)