Nitric oxide reductase (cytochrome c)

Nitric oxide reductase (cytochrome c)
Identifiers
EC number	1.7.2.5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Nitric oxide reductase (cytochrome c) (EC 1.7.2.5) is an enzyme with systematic name nitrous oxide:ferricytochrome-c oxidoreductase.^{[1][2][3][4][5][6]} This enzyme catalyses the following chemical reaction

nitrous oxide + 2 ferricytochrome c + H₂O $\rightleftharpoons$ 2 nitric oxide + 2 ferrocytochrome c + 2 H⁺

The enzyme from Pseudomonas aeruginosa contains a dinuclear centre.

References

1. Hendriks, J., Warne, A., Gohlke, U., Haltia, T., Ludovici, C., Lubben, M. and Saraste, M. (1998). "The active site of the bacterial nitric oxide reductase is a dinuclear iron center". Biochemistry 37: 13102–13109. doi:10.1021/bi980943x. PMID 9748316.
2. Hendriks, J., Gohlke, U. and Saraste, M. (1998). "From NO to OO: nitric oxide and dioxygen in bacterial respiration". J. Bioenerg. Biomembr. 30 (1): 15–24. doi:10.1023/A:1020547225398. PMID 9623801.
3. Heiss, B., Frunzke, K. and Zumpft, W.G. (1989). "Formation of the N-N bond from nitric oxide by a membrane-bound cytochrome bc complex of nitrate-respiring (denitrifying) Pseudomonas stutzeri". J. Bacteriol. 171 (6): 3288–3297. PMC 210048. PMID 2542222.
4. Cheesman, M.R., Zumft, W.G. and Thomson, A.J. (1998). "The MCD and EPR of the heme centers of nitric oxide reductase from Pseudomonas stutzeri: evidence that the enzyme is structurally related to the heme-copper oxidases". Biochemistry 37: 3994–4000. doi:10.1021/bi972437y. PMID 9521721.
5. Kumita, H., Matsuura, K., Hino, T., Takahashi, S., Hori, H., Fukumori, Y., Morishima, I. and Shiro, Y. (2004). "NO reduction by nitric-oxide reductase from denitrifying bacterium Pseudomonas aeruginosa: characterization of reaction intermediates that appear in the single turnover cycle". J. Biol. Chem. 279: 55247–55254. doi:10.1074/jbc.M409996200. PMID 15504726.
6. Hino, T., Matsumoto, Y., Nagano, S., Sugimoto, H., Fukumori, Y., Murata, T., Iwata, S. and Shiro, Y. (2010). "Structural basis of biological N₂O generation by bacterial nitric oxide reductase". Science 330: 1666–1670. doi:10.1126/science.1195591. PMID 21109633.

External links

• Nitric oxide reductase (cytochrome c) at the US National Library of Medicine Medical Subject Headings (MeSH)