Nitric oxide synthase 2 (inducible)

Nitric oxide synthase 2, inducible
Rendering of 1NSI​
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1NSI​, 2LL6​, 2NSI​, 3E7G​, 3EJ8​, 3HR4​, 4CX7​, 4NOS​
Identifiers
Symbols	NOS2 ; HEP-NOS; INOS; NOS; NOS2A
External IDs	OMIM: 163730 MGI: 97361 HomoloGene: 55473 ChEMBL: 4481 GeneCards: NOS2 Gene
EC number	1.14.13.39
Gene ontology Molecular function • NADPH-hemoprotein reductase activity • nitric-oxide synthase activity • receptor binding • iron ion binding • protein binding • calmodulin binding • FMN binding • heme binding • tetrahydrobiopterin binding • arginine binding • protein homodimerization activity • flavin adenine dinucleotide binding • NADP binding Cellular component • intracellular • nucleus • cytoplasm • peroxisome • cytosol • cortical cytoskeleton • perinuclear region of cytoplasm Biological process • response to hypoxia • positive regulation of leukocyte mediated cytotoxicity • innate immune response in mucosa • arginine catabolic process • superoxide metabolic process • nitric oxide biosynthetic process • inflammatory response • nitric oxide mediated signal transduction • blood coagulation • circadian rhythm • response to bacterium • negative regulation of gene expression • peptidyl-cysteine S-nitrosylation • positive regulation of guanylate cyclase activity • regulation of cell proliferation • negative regulation of protein catabolic process • defense response to bacterium • regulation of cellular respiration • negative regulation of blood pressure • positive regulation of vasodilation • regulation of insulin secretion • defense response to Gram-negative bacterium • interaction with host • positive regulation of killing of cells of other organism • oxidation-reduction process • cellular response to lipopolysaccharide • cellular response to interferon-gamma • phagosome maturation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4843	18126
Ensembl	ENSG00000007171	ENSMUSG00000020826
UniProt	P35228	P29477
RefSeq (mRNA)	NM_000625	NM_010927
RefSeq (protein)	NP_000616	NP_035057
Location (UCSC)	Chr 17: 27.76 – 27.8 Mb	Chr 11: 78.92 – 78.96 Mb
PubMed search

Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene.^[1]

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in the liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.^[2]

Interactions

Nitric oxide synthase 2A has been shown to interact with Caveolin 1^[3] and Rac2.^[4]

References

1. Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR (May 1993). "Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes". Proc Natl Acad Sci USA 90 (8): 3491–5. doi:10.1073/pnas.90.8.3491. PMC 46326. PMID 7682706.
2. "Entrez Gene: NOS2A nitric oxide synthase 2A (inducible, hepatocytes)".
3. Felley-Bosco E, Bender FC, Courjault-Gautier F, Bron C, Quest AF (December 2000). "Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14334–9. doi:10.1073/pnas.250406797. PMC 18919. PMID 11114180.
4. Kuncewicz T, Balakrishnan P, Snuggs MB, Kone BC (August 2001). "Specific association of nitric oxide synthase-2 with Rac isoforms in activated murine macrophages". Am. J. Physiol. Renal Physiol. 281 (2): F326–36. PMID 11457725.