O-acetylhomoserine aminocarboxypropyltransferase

O-acetylhomoserine aminocarboxypropyltransferase
Identifiers
EC number	2.5.1.49
CAS number	37290-90-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an O-acetylhomoserine aminocarboxypropyltransferase (EC 2.5.1.49) is an enzyme that catalyzes the chemical reaction

O-acetyl-L-homoserine + methanethiol $\rightleftharpoons$ L-methionine + acetate

Thus, the two substrates of this enzyme are O-acetyl-L-homoserine and methanethiol, whereas its two products are L-methionine and acetate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase. Other names in common use include O-acetyl-L-homoserine acetate-lyase (adding methanethiol), O-acetyl-L-homoserine sulfhydrolase, O-acetylhomoserine (thiol)-lyase, O-acetylhomoserine sulfhydrolase, and methionine synthase. This enzyme participates in methionine metabolism and cysteine metabolism.

References

• Kerr D (1971). "O-Acetylhomoserine sulfhydrylase (Neurospora)". Methods Enzymol. 17B: 446–450. doi:10.1016/0076-6879(71)17079-6.
• Smith IK, Thompson JF (1969). "Utilization of S-methylcysteine and methylmercaptan by methionineless mutants of Neurospora and the pathway of their conversion to methionine. II. Enzyme studies". Biochim. Biophys. Acta 184 (1): 130–8. doi:10.1016/0304-4165(69)90107-x. PMID 5791104.
• Yamagata S, Takeshima K. "O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast Further purification and characterization as a pyridoxal enzyme". J. (Tokyo). Biochem. (4): 777–85. PMID 795806.
• Yamagata S. "O-Acetylserine and O-acetylhomoserine sulfhydrylase of yeast Subunit structure". J. (Tokyo). Biochem. (4): 787–97. PMID 795807.
• Yamagata S, Takeshima K, Naiki N. "Evidence for the identity of O-acetylserine sulfhydrylase with O-acetylhomoserine sulfhydrylase in yeast". J. (Tokyo). Biochem. (6): 1221–9. PMID 4609980.
• Yamagata S (1989). "Roles of O-acetyl-L-homoserine sulfhydrylases in micro-organisms". Biochimie. 71 (11–12): 1125–43. doi:10.1016/0300-9084(89)90016-3. PMID 2517474.
• Kuramitsu S, Iwama T (2001). "Cloning and overexpression of the oah1 gene encoding O-acetyl-L-homoserine sulfhydrylase of Thermus thermophilus HB8 and characterization of the gene product". Biochim. Biophys. Acta 1549 (1): 61–72. doi:10.1016/S0167-4838(01)00245-X. PMID 11566369.