O-phospho-L-seryl-tRNA:Cys-tRNA synthase

O-phospho-L-seryl-tRNA:Cys-tRNA synthase
Identifiers
EC number	2.5.1.73
CAS number	1239229-21-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

O-phospho-L-seryl-tRNA:Cys-tRNA synthase (EC 2.5.1.73, SepCysS, Sep-tRNA:Cys-tRNA synthase) is an enzyme with systematic name O-phospho-L-seryl-tRNACys:hydrogen sulfide 2-aminopropanoate transferase.^[1][2][3] This enzyme catalyses the following chemical reaction

O-phospho-L-seryl-tRNACys + sulfide $\rightleftharpoons$ L-cysteinyl-tRNACys + phosphate

References

1. Fukunaga, R. and Yokoyama, S. (2007). "Structural insights into the second step of RNA-dependent cysteine biosynthesis in archaea: crystal structure of Sep-tRNA:Cys-tRNA synthase from Archaeoglobus fulgidus". J. Mol. Biol. 370 (1): 128–141. doi:10.1016/j.jmb.2007.04.050. PMID 17512006.
2. Hauenstein, S.I. and Perona, J.J. (2008). "Redundant synthesis of cysteinyl-tRNA^Cys in Methanosarcina mazei". J. Biol. Chem. 283 (32): 22007–22017. doi:10.1074/jbc.M801839200. PMC 2494925. PMID 18559341.
3. Yuan, J., Palioura, S., Salazar, J.C., Su, D., O'Donoghue, P., Hohn, M.J., Cardoso, A.M., Whitman, W.B. and Soll, D. (2006). "RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea". Proc. Natl. Acad. Sci. USA 103 (50): 18923–18927. Bibcode:2006PNAS..10318923Y. doi:10.1073/pnas.0609703104. PMC 1748153. PMID 17142313.

External links

• O-phospho-L-seryl-tRNA:Cys-tRNA synthase at the US National Library of Medicine Medical Subject Headings (MeSH)