O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase

O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase
Identifiers
EC number	2.9.1.2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase (EC 2.9.1.2, MMPSepSecS, SepSecS, SLA/LP, O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase, O-phospho-L-seryl-tRNA:L-selenocysteinyl-tRNA synthase) is an enzyme with systematic name selenophosphate:O-phospho-L-seryl-tRNASec selenium transferase.^[1][2][3][4] This enzyme catalyses the following chemical reaction

O-phospho-L-seryl-tRNASec + selenophosphate $\rightleftharpoons$ L-selenocysteinyl-tRNASec + phosphate

This enzyme is pyridoxal-phosphate protein.

References

1. Palioura, S., Sherrer, R.L., Steitz, T.A., Soll, D. and Simonovic, M. (2009). "The human SepSecS-tRNA^Sec complex reveals the mechanism of selenocysteine formation". Science 325: 321–325. doi:10.1126/science.1173755. PMID 19608919.
2. Araiso, Y., Palioura, S., Ishitani, R., Sherrer, R.L., O'Donoghue, P., Yuan, J., Oshikane, H., Domae, N., Defranco, J., Soll, D. and Nureki, O. (2008). "Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation". Nucleic Acids Res. 36: 1187–1199. doi:10.1093/nar/gkm1122. PMID 18158303.
3. Aeby, E., Palioura, S., Pusnik, M., Marazzi, J., Lieberman, A., Ullu, E., Soll, D. and Schneider, A. (2009). "The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes". Proc. Natl. Acad. Sci. USA 106: 5088–5092. doi:10.1073/pnas.0901575106. PMID 19279205.
4. Yuan, J., Palioura, S., Salazar, J.C., Su, D., O'Donoghue, P., Hohn, M.J., Cardoso, A.M., Whitman, W.B. and Soll, D. (2006). "RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea". Proc. Natl. Acad. Sci. USA 103: 18923–18927. doi:10.1073/pnas.0609703104. PMC 1748153. PMID 17142313.

External links

• O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase at the US National Library of Medicine Medical Subject Headings (MeSH)