Phosphocholine
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| Names | |
|---|---|
| Other names
Choline phosphate | |
| Identifiers | |
107-73-3  | |
| ChemSpider | 119298 |
| Jmol interactive 3D | Image |
| MeSH | Phosphocholine |
| PubChem | 1014 |
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| Properties | |
| C5H15NO4P+ | |
| Molar mass | 184.151 g/mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is  ?) | |
| Infobox references | |
- Not to be confused with phosphatidylcholine.
Phosphocholine is an intermediate in the synthesis of phosphatidylcholine in tissues. Phosphocholine is made in a reaction, catalyzed by choline kinase, that converts ATP and choline into phosphocholine and ADP. Phosphocholine is a molecule found, for example, in lecithin.
It is also used by nematodes and human placentas as a posttranslational modification to suppress an immune response by their hosts.[1][2]
It is also one of the binding targets of C-reactive protein (CRP).[3] Thus, when a cell is damaged, CRP binds to phosphocholine, beginning the recognition and phagocytotic immunologic response.
Phosphocholine is a natural constituent of hens' eggs (and many other eggs) often used in biomimetic membrane studies.[4]
See also
References
- ↑ Lovell TM, Woods RJ, Butlin DJ, et al. (September 2007). "Identification of a novel mammalian post-translational modification, phosphocholine, on placental secretory polypeptides". J. Mol. Endocrinol. 39 (3): 189–98. doi:10.1677/JME-07-0007. PMC 2189575. PMID 17766644.
- ↑ "Placenta 'fools body's defences'". BBC News. 2007-11-10. Retrieved 2010-05-22.
- ↑ Thompson D, Pepys MB, Wood SP. (1999). "The physiological structure of human C-reactive protein and its complex with phosphocholine.". Structure 7 (2): 169–77. doi:10.1016/S0969-2126(99)80023-9. PMID 10368284.
- ↑ Rose L, Jenkins ATA (2006). "The effect of the ionophore valinomycin on biomimetic solid supported lipid DPPTE/EPC membranes". Bioelectrochem. 70 (2): 387–93. doi:10.1016/j.bioelechem.2006.05.009. PMID 16875886.
External links
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