PABPC3

Poly(A) binding protein, cytoplasmic 3
PDB rendering based on 1g9l.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2D9P​, 4IVE​
Identifiers
Symbols	PABPC3 ; PABP3; PABPL3; tPABP
External IDs	OMIM: 604680 HomoloGene: 118007 GeneCards: PABPC3 Gene
Gene ontology Molecular function • nucleotide binding • poly(A) binding Cellular component • cytoplasm • extracellular exosome Biological process • mRNA metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5042	n/a
Ensembl	ENSG00000151846	n/a
UniProt	Q9H361	n/a
RefSeq (mRNA)	NM_030979	n/a
RefSeq (protein)	NP_112241	n/a
Location (UCSC)	Chr 13: 25.1 – 25.1 Mb	n/a
PubMed search		n/a

Polyadenylate-binding protein 3 is a protein that in humans is encoded by the PABPC3 gene.^[1][2][3]

Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM]^[3]

References

1. Morris CM, Bodger MP (Mar 1993). "Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization". Genomics 15 (1): 209–11. doi:10.1006/geno.1993.1037. PMID 8432538.
2. Feral C, Mattei MG, Pawlak A, Guellaen G (Nov 1999). "Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes". Hum Genet 105 (4): 347–53. doi:10.1007/s004390051113. PMC 1865476. PMID 10543404.
3. "Entrez Gene: PABPC3 poly(A) binding protein, cytoplasmic 3".

Further reading

• Marques AC, Dupanloup I, Vinckenbosch N, et al. (2006). "Emergence of young human genes after a burst of retroposition in primates.". PLoS Biol. 3 (11): e357. doi:10.1371/journal.pbio.0030357. PMC 1251493. PMID 16201836.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Féral C, Guellaën G, Pawlak A (2002). "Human testis expresses a specific poly(A)-binding protein.". Nucleic Acids Res. 29 (9): 1872–83. doi:10.1093/nar/29.9.1872. PMC 37253. PMID 11328870.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Hoshino S, Imai M, Kobayashi T, et al. (1999). "The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein.". J. Biol. Chem. 274 (24): 16677–80. doi:10.1074/jbc.274.24.16677. PMID 10358005.