ILF2
| Interleukin enhancer binding factor 2 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | ILF2 ; NF45; PRO3063 | ||||||||||||
| External IDs | OMIM: 603181 MGI: 1915031 HomoloGene: 26894 GeneCards: ILF2 Gene | ||||||||||||
| |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 3608 | 67781 | |||||||||||
| Ensembl | ENSG00000143621 | ENSMUSG00000001016 | |||||||||||
| UniProt | Q12905 | Q9CXY6 | |||||||||||
| RefSeq (mRNA) | NM_001267809 | NM_026374 | |||||||||||
| RefSeq (protein) | NP_001254738 | NP_080650 | |||||||||||
| Location (UCSC) |
Chr 1: 153.66 – 153.67 Mb |
Chr 3: 90.48 – 90.49 Mb | |||||||||||
| PubMed search | |||||||||||||
Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene.[1][2]
Function
Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.[2]
Interactions
ILF2 has been shown to interact with CDC5L[3] and DNA-PKcs.[4]
References
- ↑ Kao PN, Chen L, Brock G, Ng J, Kenny J, Smith AJ, Corthésy B (Aug 1994). "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90". The Journal of Biological Chemistry 269 (32): 20691–9. PMID 7519613.
- 1 2 "Entrez Gene: ILF2 interleukin enhancer binding factor 2, 45kDa".
- ↑ Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
- ↑ Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (Jan 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.
Further reading
- Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Marcoulatos P, Koussidis G, Mamuris Z, Velissariou V, Vamvakopoulos NC (Dec 1996). "Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates". Journal of Interferon & Cytokine Research 16 (12): 1035–8. doi:10.1089/jir.1996.16.1035. PMID 8974006.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (Jan 1998). "DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45". The Journal of Biological Chemistry 273 (4): 2136–45. doi:10.1074/jbc.273.4.2136. PMID 9442054.
- Langland JO, Kao PN, Jacobs BL (May 1999). "Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR". Biochemistry 38 (19): 6361–8. doi:10.1021/bi982410u. PMID 10320367.
- Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (Dec 1999). "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity". The Journal of Biological Chemistry 274 (49): 34598–604. doi:10.1074/jbc.274.49.34598. PMID 10574923.
- Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (Dec 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". The EMBO Journal 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
- Parker LM, Fierro-Monti I, Mathews MB (Aug 2001). "Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase". The Journal of Biological Chemistry 276 (35): 32522–30. doi:10.1074/jbc.M104408200. PMID 11438540.
- Reichman TW, Muñiz LC, Mathews MB (Jan 2002). "The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells". Molecular and Cellular Biology 22 (1): 343–56. doi:10.1128/MCB.22.1.343-356.2002. PMC 134226. PMID 11739746.
- Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (Jan 2002). "Directed proteomic analysis of the human nucleolus". Current Biology 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
- Shin HJ, Kim SS, Cho YH, Lee SG, Rho HM (Mar 2002). "Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA". Archives of Virology 147 (3): 471–91. doi:10.1007/s007050200001. PMID 11958450.
- Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (Nov 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
- Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (Nov 2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins". Molecular and Cellular Biology 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
- Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
- Zhao G, Shi L, Qiu D, Hu H, Kao PN (May 2005). "NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function". Experimental Cell Research 305 (2): 312–23. doi:10.1016/j.yexcr.2004.12.030. PMID 15817156.
- Nie Y, Ding L, Kao PN, Braun R, Yang JH (Aug 2005). "ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing". Molecular and Cellular Biology 25 (16): 6956–63. doi:10.1128/MCB.25.16.6956-6963.2005. PMC 1190226. PMID 16055709.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
External links
- ILF2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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