V-erbA-related gene

Nuclear receptor subfamily 2, group F, member 6
Identifiers
Symbols	NR2F6 ; EAR-2; EAR2; ERBAL2
External IDs	OMIM: 132880 MGI: 1352453 HomoloGene: 7706 IUPHAR: 619 GeneCards: NR2F6 Gene
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • DNA binding • transcription factor activity, sequence-specific DNA binding • steroid hormone receptor activity • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • thyroid hormone receptor activity • protein binding • zinc ion binding • sequence-specific DNA binding Cellular component • nucleus • nucleoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • signal transduction • gene expression • intracellular receptor signaling pathway • entrainment of circadian clock by photoperiod • steroid hormone mediated signaling pathway • neuron development • detection of temperature stimulus involved in sensory perception of pain Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2063	13864
Ensembl	ENSG00000160113	ENSMUSG00000002393
UniProt	P10588	P43136
RefSeq (mRNA)	NM_005234	NM_010150
RefSeq (protein)	NP_005225	NP_034280
Location (UCSC)	Chr 19: 17.23 – 17.25 Mb	Chr 8: 71.37 – 71.38 Mb
PubMed search

V-erbA-related protein 2 (EAR-2) also known as NR2F6 (nuclear receptor subfamily 2 group F member 6) is a protein that in humans is encoded by the NR2F6 gene.^[1] V-erbA-related protein 2 is a member of the nuclear receptor family of intracellular transcription factors.

Function

Comparatively little is known about ear-2, but it has been shown to function as a coregulator of other nuclear receptors.^[2][3]

Nr2f6 knockout mice show defects in development of the locus ceruleus.^[4]

Interactions

V-erbA-related gene has been shown to interact with:

• COUP-TFII^[5]
• Thyroid hormone receptor beta^[2]

References

1. Miyajima N, Kadowaki Y, Fukushige S, Shimizu S, Semba K, Yamanashi Y, Matsubara K, Toyoshima K, Yamamoto T (December 1988). "Identification of two novel members of erbA superfamily by molecular cloning: the gene products of the two are highly related to each other". Nucleic Acids Research 16 (23): 11057–74. doi:10.1093/nar/16.23.11057. PMC 338996. PMID 2905047.
2. Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function". Molecular and Cellular Biology 20 (7): 2604–18. doi:10.1128/MCB.20.7.2604-2618.2000. PMC 85476. PMID 10713182.
3. Liu X, Huang X, Sigmund CD (May 2003). "Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription". Circulation Research 92 (9): 1033–40. doi:10.1161/01.RES.0000071355.82009.43. PMID 12690040.
4. Warnecke M, Oster H, Revelli JP, Alvarez-Bolado G, Eichele G (March 2005). "Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception". Genes & Development 19 (5): 614–25. doi:10.1101/gad.317905. PMC 551581. PMID 15741322.
5. Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M (May 1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". The Journal of Biological Chemistry 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855.

Further reading

• Bähler M, Kehrer I, Gordon L, Stoffler HE, Olsen AS (July 1997). "Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1". Genomics 43 (1): 107–9. doi:10.1006/geno.1997.4776. PMID 9226381.
• Avram D, Ishmael JE, Nevrivy DJ, Peterson VJ, Lee SH, Dowell P, Leid M (May 1999). "Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2". The Journal of Biological Chemistry 274 (20): 14331–6. doi:10.1074/jbc.274.20.14331. PMC 2823254. PMID 10318855.
• Zhang Y, Dufau ML (January 2000). "Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor". The Journal of Biological Chemistry 275 (4): 2763–70. doi:10.1074/jbc.275.4.2763. PMID 10644740.
• Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY (April 2000). "The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function". Molecular and Cellular Biology 20 (7): 2604–18. doi:10.1128/MCB.20.7.2604-2618.2000. PMC 85476. PMID 10713182.
• Liu X, Huang X, Sigmund CD (May 2003). "Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription". Circulation Research 92 (9): 1033–40. doi:10.1161/01.RES.0000071355.82009.43. PMID 12690040.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.

External links

• NR2F6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)