LYL1

Lymphoblastic leukemia associated hematopoiesis regulator 1
Identifiers
Symbols	LYL1 ; bHLHa18
External IDs	OMIM: 151440 MGI: 96891 HomoloGene: 4078 GeneCards: LYL1 Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • DNA binding • protein binding • protein dimerization activity Cellular component • nucleus Biological process • blood vessel maturation • transcription, DNA-templated • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • B cell differentiation • positive regulation of transcription, DNA-templated • definitive hemopoiesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4066	17095
Ensembl	ENSG00000104903	ENSMUSG00000034041
UniProt	P12980	P27792
RefSeq (mRNA)	NM_005583	NM_008535
RefSeq (protein)	NP_005574	NP_032561
Location (UCSC)	Chr 19: 13.1 – 13.1 Mb	Chr 8: 84.7 – 84.7 Mb
PubMed search

Protein lyl-1 is a protein that in humans is encoded by the LYL1 gene.^[1][2]

Interactions

LYL1 has been shown to interact with TCF3^[3] and NFKB1.^[4]

References

1. Mellentin JD, Smith SD, Cleary ML (Aug 1989). "lyl-1, a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif". Cell 58 (1): 77–83. doi:10.1016/0092-8674(89)90404-2. PMID 2752424.
2. "Entrez Gene: LYL1 lymphoblastic leukemia derived sequence 1".
3. Miyamoto, A; Cui X; Naumovski L; Cleary M L (May 1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells". Mol. Cell. Biol. (UNITED STATES) 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. ISSN 0270-7306. PMC 231228. PMID 8628307.
4. Ferrier, R; Nougarede R; Doucet S; Kahn-Perles B; Imbert J; Mathieu-Mahul D (Jan 1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105". Oncogene (ENGLAND) 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. ISSN 0950-9232. PMID 10023675.

Further reading

• Xia Y, Brown L, Yang CY, et al. (1992). "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia.". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. doi:10.1073/pnas.88.24.11416. PMC 53146. PMID 1763056.
• Kuo SS, Mellentin JD, Copeland NG, et al. (1991). "Structure, chromosome mapping, and expression of the mouse Lyl-1 gene.". Oncogene 6 (6): 961–8. PMID 2067848.
• Saltman DL, Mellentin JD, Smith SD, Cleary ML (1991). "Mapping of translocation breakpoints on the short arm of chromosome 19 in acute leukemias by in situ hybridization.". Genes Chromosomes Cancer 2 (4): 259–65. doi:10.1002/gcc.2870020402. PMID 2268576.
• Wadman I, Li J, Bash RO, et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.". EMBO J. 13 (20): 4831–9. PMC 395422. PMID 7957052.
• Trask B, Fertitta A, Christensen M, et al. (1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers.". Genomics 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.
• Miyamoto A, Cui X, Naumovski L, Cleary ML (1996). "Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells.". Mol. Cell. Biol. 16 (5): 2394–401. doi:10.1128/mcb.16.5.2394. PMC 231228. PMID 8628307.
• Mahajan MA, Park ST, Sun XH (1996). "Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins.". Oncogene 12 (11): 2343–50. PMID 8649774.
• Ferrier R, Nougarede R, Doucet S, et al. (1999). "Physical interaction of the bHLH LYL1 protein and NF-kappaB1 p105.". Oncogene 18 (4): 995–1005. doi:10.1038/sj.onc.1202374. PMID 10023675.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Meng YS, Khoury H, Dick JE, Minden MD (2005). "Oncogenic potential of the transcription factor LYL1 in acute myeloblastic leukemia.". Leukemia 19 (11): 1941–7. doi:10.1038/sj.leu.2403836. PMID 16094422.

External links

• LYL1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)