FOXF1

Forkhead box F1
Identifiers
Symbols	FOXF1 ; ACDMPV; FKHL5; FREAC1
External IDs	OMIM: 601089 MGI: 1347470 HomoloGene: 1114 GeneCards: FOXF1 Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • sequence-specific DNA binding Cellular component • nucleus • transcription factor complex Biological process • negative regulation of transcription from RNA polymerase II promoter • blood vessel development • vasculogenesis • in utero embryonic development • somitogenesis • morphogenesis of a branching structure • positive regulation of mesenchymal cell proliferation • endocardial cushion development • cardiac left ventricle morphogenesis • transcription from RNA polymerase II promoter • smoothened signaling pathway • determination of left/right symmetry • midgut development • heart development • positive regulation of cell-substrate adhesion • detection of wounding • single organismal cell-cell adhesion • cell differentiation • extracellular matrix organization • respiratory tube development • lung development • positive regulation of cell migration • pancreas development • negative regulation of mast cell degranulation • establishment of epithelial cell apical/basal polarity • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • lung alveolus development • lateral mesodermal cell differentiation • embryonic digestive tract morphogenesis • digestive tract development • embryonic ectodermal digestive tract morphogenesis • embryonic foregut morphogenesis • negative regulation of inflammatory response • smooth muscle cell differentiation • regulation of smooth muscle cell differentiation • lung vasculature development • trachea development • epithelial tube branching involved in lung morphogenesis • branching involved in open tracheal system development • right lung morphogenesis • lung lobe morphogenesis • venous blood vessel development • epithelial cell differentiation involved in mammary gland alveolus development • cellular response to cytokine stimulus • cellular response to organic cyclic compound • renal system development • ureter development • mesenchyme migration • ductus arteriosus closure Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2294	15227
Ensembl	ENSG00000103241	ENSMUSG00000042812
UniProt	Q12946	Q61080
RefSeq (mRNA)	NM_001451	NM_010426
RefSeq (protein)	NP_001442	NP_034556
Location (UCSC)	Chr 16: 86.51 – 86.52 Mb	Chr 8: 121.08 – 121.09 Mb
PubMed search

Forkhead box protein F1 is a protein that in humans is encoded by the FOXF1 gene.^[1][2][3]

Function

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development.^[3]

References

1. Larsson C, Hellqvist M, Pierrou S, White I, Enerbäck S, Carlsson P (Dec 1995). "Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics 30 (3): 464–9. doi:10.1006/geno.1995.1266. PMID 8825632.
2. Pierrou S, Hellqvist M, Samuelsson L, Enerbäck S, Carlsson P (Oct 1994). "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". The EMBO Journal 13 (20): 5002–12. PMC 395442. PMID 7957066.
3. "Entrez Gene: FOXF1 forkhead box F1".

Further reading

• Murphy DB, Wiese S, Burfeind P, Schmundt D, Mattei MG, Schulz-Schaeffer W, Thies U (Jun 1994). "Human brain factor 1, a new member of the fork head gene family". Genomics 21 (3): 551–7. doi:10.1006/geno.1994.1313. PMID 7959731.
• Hellqvist M, Mahlapuu M, Samuelsson L, Enerbäck S, Carlsson P (Feb 1996). "Differential activation of lung-specific genes by two forkhead proteins, FREAC-1 and FREAC-2". The Journal of Biological Chemistry 271 (8): 4482–90. doi:10.1074/jbc.271.8.4482. PMID 8626802.
• Hellqvist M, Mahlapuu M, Blixt A, Enerbäck S, Carlsson P (Sep 1998). "The human forkhead protein FREAC-2 contains two functionally redundant activation domains and interacts with TBP and TFIIB". The Journal of Biological Chemistry 273 (36): 23335–43. doi:10.1074/jbc.273.36.23335. PMID 9722567.
• Mahlapuu M, Pelto-Huikko M, Aitola M, Enerbäck S, Carlsson P (Oct 1998). "FREAC-1 contains a cell-type-specific transcriptional activation domain and is expressed in epithelial-mesenchymal interfaces". Developmental Biology 202 (2): 183–95. doi:10.1006/dbio.1998.9010. PMID 9769171.
• Coon DR, Roberts DJ, Loscertales M, Kradin R (Apr 2006). "Differential epithelial expression of SHH and FOXF1 in usual and nonspecific interstitial pneumonia". Experimental and Molecular Pathology 80 (2): 119–23. doi:10.1016/j.yexmp.2005.12.003. PMID 16448649.
• Lomenick JP, Hubert MA, Handwerger S (Nov 2006). "Transcription factor FOXF1 regulates growth hormone variant gene expression". American Journal of Physiology. Endocrinology and Metabolism 291 (5): E947–51. doi:10.1152/ajpendo.00128.2006. PMID 16772323.

External links

• FOXF1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.