SPIB

Spi-B transcription factor (Spi-1/PU.1 related)
Identifiers
Symbols	SPIB ; SPI-B
External IDs	OMIM: 606802 MGI: 892986 HomoloGene: 79220 GeneCards: SPIB Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding Cellular component • nucleus • cytoplasm Biological process • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6689	272382
Ensembl	ENSG00000269404	ENSMUSG00000008193
UniProt	Q01892	O35906
RefSeq (mRNA)	NM_001243998	NM_019866
RefSeq (protein)	NP_001230927	NP_063919
Location (UCSC)	Chr 19: 50.42 – 50.43 Mb	Chr 7: 44.53 – 44.53 Mb
PubMed search

Transcription factor Spi-B is a protein that in humans is encoded by the SPIB gene.^[1][2]

SPI1 (MIM 165170) and SPIB are members of a subfamily of ETS (see ETS1; MIM 164720) transcription factors. ETS proteins share a conserved ETS domain that mediates specific DNA binding. SPIB and SPI1 bind to a purine-rich sequence, the PU box (5-prime-GAGGAA-3-prime).[supplied by OMIM]^[2]

Interactions

SPIB has been shown to interact with MAPK3^[3] and MAPK8.^[3]

References

1. Ray D, Bosselut R, Ghysdael J, Mattei MG, Tavitian A, Moreau-Gachelin F (October 1992). "Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1". Mol Cell Biol 12 (10): 4297–304. PMC 360353. PMID 1406622.
2. "Entrez Gene: SPIB Spi-B transcription factor (Spi-1/PU.1 related)".
3. Mao, C; Ray-Gallet D; Tavitian A; Moreau-Gachelin F (February 1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene (ENGLAND) 12 (4): 863–73. ISSN 0950-9232. PMID 8632909.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Mao C, Ray-Gallet D, Tavitian A, Moreau-Gachelin F (1996). "Differential phosphorylations of Spi-B and Spi-1 transcription factors". Oncogene 12 (4): 863–73. PMID 8632909.
• Ray-Gallet D, Tavitian A, Moreau-Gachelin F (1996). "An alternatively spliced isoform of the Spi-B transcription factor". Biochem. Biophys. Res. Commun. 223 (2): 257–63. doi:10.1006/bbrc.1996.0881. PMID 8670269.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Rao S, Matsumura A, Yoon J, Simon MC (1999). "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1". J. Biol. Chem. 274 (16): 11115–24. doi:10.1074/jbc.274.16.11115. PMID 10196196.
• Nagy M, Chapuis B, Matthes T (2002). "Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells". Br. J. Haematol. 116 (2): 429–35. doi:10.1046/j.1365-2141.2002.03271.x. PMID 11841448.
• Yamamoto H, Kihara-Negishi F, Yamada T, et al. (2002). "Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb". Cell Growth Differ. 13 (2): 69–75. PMID 11864910.
• Schotte R, Rissoan MC, Bendriss-Vermare N, et al. (2003). "The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development". Blood 101 (3): 1015–23. doi:10.1182/blood-2002-02-0438. PMID 12393575.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Schotte R, Nagasawa M, Weijer K, et al. (2005). "The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development". J. Exp. Med. 200 (11): 1503–9. doi:10.1084/jem.20041231. PMC 2211952. PMID 15583020.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Geng CD, Vedeckis WV (2006). "c-Myb and members of the c-Ets family of transcription factors act as molecular switches to mediate opposite steroid regulation of the human glucocorticoid receptor 1A promoter". J. Biol. Chem. 280 (52): 43264–71. doi:10.1074/jbc.M508245200. PMID 16263717.
• Dontje W, Schotte R, Cupedo T, et al. (2006). "Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B". Blood 107 (6): 2446–52. doi:10.1182/blood-2005-05-2090. PMID 16317090.

External links

• SPIB protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.