IRX5
| Iroquois homeobox 5 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | IRX5 ; HMMS; IRX-2a; IRXB2 | ||||||||||||
| External IDs | OMIM: 606195 MGI: 1859086 HomoloGene: 38105 GeneCards: IRX5 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 10265 | 54352 | |||||||||||
| Ensembl | ENSG00000176842 | ENSMUSG00000031737 | |||||||||||
| UniProt | P78411 | Q9JKQ4 | |||||||||||
| RefSeq (mRNA) | NM_001252197 | NM_018826 | |||||||||||
| RefSeq (protein) | NP_001239126 | NP_061296 | |||||||||||
| Location (UCSC) |
Chr 16: 54.93 – 54.93 Mb |
Chr 8: 92.36 – 92.36 Mb | |||||||||||
| PubMed search | |||||||||||||
Iroquois-class homeodomain protein IRX-5, also known as Iroquois homeobox protein 5, is a protein that in humans is encoded by the IRX5 gene.[1][2]
Function
IRX5 is a member of the Iroquois homeobox gene family. Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[1]
References
- 1 2 "Entrez Gene: iroquois homeobox 1".
- ↑ Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T (2001). "Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes". Cytogenet. Cell Genet. 92 (3-4): 320–5. doi:10.1159/000056921. PMID 11435706.
Further reading
- Lewis MT, Ross S, Strickland PA, et al. (1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast.". Cell Tissue Res. 296 (3): 549–54. doi:10.1007/s004410051316. PMID 10370142.
- Bruneau BG (2006). "[Irx5: a transcription factor that regulates the cardiac repolarization gradient]". Med Sci (Paris) 22 (3): 231–2. doi:10.1051/medsci/2006223231. PMID 16527195.
- Myrthue A, Rademacher BL, Pittsenbarger J, et al. (2008). "The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cells.". Clin. Cancer Res. 14 (11): 3562–70. doi:10.1158/1078-0432.CCR-07-4649. PMID 18519790.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kanno S, Kuzuoka H, Sasao S, et al. (2007). "A novel human AP endonuclease with conserved zinc-finger-like motifs involved in DNA strand break responses.". EMBO J. 26 (8): 2094–103. doi:10.1038/sj.emboj.7601663. PMC 1852789. PMID 17396150.
External links
- IRX5 human gene location in the UCSC Genome Browser.
- IRX5 human gene details in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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