NFE2

Nuclear factor, erythroid 2
Rendering based on PDB 1LVX​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1LVX​, 2KZ5​
Identifiers
Symbols	NFE2 ; NF-E2; p45
External IDs	OMIM: 601490 MGI: 97308 HomoloGene: 4491 GeneCards: NFE2 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • protein binding • sequence-specific DNA binding • protein N-terminus binding • WW domain binding Cellular component • nucleus • nucleoplasm • cytoplasm • actin cytoskeleton • PML body Biological process • nucleosome disassembly • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • multicellular organismal development • blood coagulation • hemostasis • blood circulation • positive regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4778	18022
Ensembl	ENSG00000123405	ENSMUSG00000058794
UniProt	Q16621	Q07279
RefSeq (mRNA)	NM_001136023	NM_001302338
RefSeq (protein)	NP_001129495	NP_001289267
Location (UCSC)	Chr 12: 54.29 – 54.3 Mb	Chr 15: 103.25 – 103.26 Mb
PubMed search

Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene.^[1][2]

It is involved in megakaryocyte production.^[3]

Interactions

NFE2 has been shown to interact with CREB-binding protein.^[4]

References

1. Ney PA, Andrews NC, Jane SM, Safer B, Purucker ME, Weremowicz S, Morton CC, Goff SC, Orkin SH, Nienhuis AW (Sep 1993). "Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner". Mol Cell Biol 13 (9): 5604–12. PMC 360284. PMID 8355703.
2. "Entrez Gene: NFE2 nuclear factor (erythroid-derived 2), 45kDa".
3. Gasiorek JJ, Blank V (2015). "Regulation and function of the NFE2 transcription factor in hematopoietic and non-hematopoietic cells". Cellular and Molecular Life Sciences 72 (12): 2323–2335.
4. Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (Apr 2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation". J. Biol. Chem. 276 (14): 10715–21. doi:10.1074/jbc.M007846200. PMID 11154691.

Further reading

• Strauss EC, Andrews NC, Higgs DR, Orkin SH (1992). "In vivo footprinting of the human alpha-globin locus upstream regulatory element by guanine and adenine ligation-mediated polymerase chain reaction.". Mol. Cell. Biol. 12 (5): 2135–42. PMC 364385. PMID 1569944.
• Pischedda C, Cocco S, Melis A, Marini MG, Kan YW, Cao A, Moi P (1995). "Isolation of a differentially regulated splicing isoform of human NF-E2". Proc. Natl. Acad. Sci. U.S.A. 92 (8): 3511–5. doi:10.1073/pnas.92.8.3511. PMC 42197. PMID 7724591.
• Shivdasani RA, Rosenblatt MF, Zucker-Franklin D, Jackson CW, Hunt P, Saris CJ, Orkin SH (1995). "Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development". Cell 81 (5): 695–704. doi:10.1016/0092-8674(95)90531-6. PMID 7774011.
• Igarashi K, Kataoka K, Itoh K, Hayashi N, Nishizawa M, Yamamoto M (1994). "Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins". Nature 367 (6463): 568–72. doi:10.1038/367568a0. PMID 8107826.
• Chan JY, Han XL, Kan YW (1994). "Isolation of cDNA encoding the human NF-E2 protein". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11366–70. doi:10.1073/pnas.90.23.11366. PMC 47983. PMID 8248255.
• Toki T, Itoh J, Kitazawa J, Arai K, Hatakeyama K, Akasaka J, Igarashi K, Nomura N, Yokoyama M, Yamamoto M, Ito E (1997). "Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif". Oncogene 14 (16): 1901–10. doi:10.1038/sj.onc.1201024. PMID 9150357.
• Blank V, Kim MJ, Andrews NC (1997). "Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression". Blood 89 (11): 3925–35. PMID 9166829.
• Gavva NR, Gavva R, Ermekova K, Sudol M, Shen CJ (1997). "Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II". J. Biol. Chem. 272 (39): 24105–8. doi:10.1074/jbc.272.39.24105. PMID 9305852.
• Mosser EA, Kasanov JD, Forsberg EC, Kay BK, Ney PA, Bresnick EH (1998). "Physical and functional interactions between the transactivation domain of the hematopoietic transcription factor NF-E2 and WW domains". Biochemistry 37 (39): 13686–95. doi:10.1021/bi981310l. PMID 9753456.
• Hung HL, Kim AY, Hong W, Rakowski C, Blobel GA (2001). "Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation". J. Biol. Chem. 276 (14): 10715–21. doi:10.1074/jbc.M007846200. PMID 11154691.
• Gavva NR, Wen SC, Daftari P, Moniwa M, Yang WM, Yang-Feng LP, Seto E, Davie JR, Shen CK (2002). "NAPP2, a peroxisomal membrane protein, is also a transcriptional corepressor". Genomics 79 (3): 423–31. doi:10.1006/geno.2002.6714. PMID 11863372.
• Boulanger L, Sabatino DE, Wong EY, Cline AP, Garrett LJ, Garbarz M, Dhermy D, Bodine DM, Gallagher PG (2003). "Erythroid expression of the human alpha-spectrin gene promoter is mediated by GATA-1- and NF-E2-binding proteins". J. Biol. Chem. 277 (44): 41563–70. doi:10.1074/jbc.M208184200. PMID 12196550.
• Marini MG, Asunis I, Chan K, Chan JY, Kan YW, Porcu L, Cao A, Moi P (2003). "Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation". Blood Cells Mol. Dis. 29 (2): 145–58. doi:10.1006/bcmd.2002.0550. PMID 12490281.
• Onishi Y, Kiyama R (2003). "Interaction of NF-E2 in the human beta-globin locus control region before chromatin remodeling". J. Biol. Chem. 278 (10): 8163–71. doi:10.1074/jbc.M209612200. PMID 12509425.
• Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science 300 (5628): 2097–101. doi:10.1126/science.1084648. PMID 12805554.
• Chuen CK, Li K, Yang M, Fok TF, Li CK, Chui CM, Yuen PM (2004). "Interleukin-1beta up-regulates the expression of thrombopoietin and transcription factors c-Jun, c-Fos, GATA-1, and NF-E2 in megakaryocytic cells". J. Lab. Clin. Med. 143 (2): 75–88. doi:10.1016/j.lab.2003.09.006. PMID 14966463.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

• NFE2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook NF-E2

This article incorporates text from the United States National Library of Medicine, which is in the public domain.