NEUROD2

Neuronal differentiation 2
Identifiers
Symbols	NEUROD2 ; NDRF; bHLHa1
External IDs	OMIM: 601725 MGI: 107755 HomoloGene: 4489 GeneCards: NEUROD2 Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • transcription corepressor activity • protein heterodimerization activity • E-box binding Cellular component • nucleus Biological process • behavioral fear response • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • nervous system development • associative learning • protein ubiquitination • cerebellar cortex development • positive regulation of synaptic plasticity • positive regulation of neuron differentiation • positive regulation of transcription from RNA polymerase II promoter • neuron development • positive regulation of calcium-mediated signaling • positive regulation of sequence-specific DNA binding transcription factor activity • cellular response to electrical stimulus • cellular response to calcium ion • positive regulation of synapse maturation • negative regulation of nucleic acid-templated transcription • negative regulation of synapse maturation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4761	18013
Ensembl	ENSG00000171532	ENSMUSG00000038255
UniProt	Q15784	Q62414
RefSeq (mRNA)	NM_006160	NM_010895
RefSeq (protein)	NP_006151	NP_035025
Location (UCSC)	Chr 17: 39.6 – 39.61 Mb	Chr 11: 98.33 – 98.33 Mb
PubMed search

Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.^[1][2]

Function

This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.^[2]

Interactions

NEUROD2 has been shown to interact with Protein kinase N1.^[3]

References

1. Tamimi RM, Steingrimsson E, Montgomery-Dyer K, Copeland NG, Jenkins NA, Tapscott SJ (Mar 1997). "NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and 5q23-q31 and mouse chromosomes 11 and 13, respectively". Genomics 40 (2): 355–7. doi:10.1006/geno.1996.4578. PMID 9119405.
2. "Entrez Gene: NEUROD2 neurogenic differentiation 2".
3. Shibata H, Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y (Dec 1999). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Research. Molecular Brain Research 74 (1-2): 126–34. doi:10.1016/S0169-328X(99)00273-9. PMID 10640683.

Further reading

• McCormick MB, Tamimi RM, Snider L, Asakura A, Bergstrom D, Tapscott SJ (Oct 1996). "NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family". Molecular and Cellular Biology 16 (10): 5792–800. doi:10.1128/mcb.16.10.5792. PMC 231580. PMID 8816493.
• Kume H, Maruyama K, Shinozaki K, Kuzume H, Obata K (Sep 1998). "Phosphorylation and spatiotemporal distribution of KW8 (NDRF/NeuroD2), a NeuroD family basic helix-loop-helix protein". Brain Research. Molecular Brain Research 60 (1): 107–14. doi:10.1016/S0169-328X(98)00176-4. PMID 9748526.
• Kitamura T, Miyachi T, Nakamura S, Kawakami H (Apr 1999). "Identification and analysis of the promoter region of the human NeuroD-related factor (NDRF)1". Biochimica et Biophysica Acta 1445 (1): 142–7. doi:10.1016/s0167-4781(99)00038-x. PMID 10209266.
• Shibata H, Oda H, Mukai H, Oishi K, Misaki K, Ohkubo H, Ono Y (Dec 1999). "Interaction of PKN with a neuron-specific basic helix-loop-helix transcription factor, NDRF/NeuroD2". Brain Research. Molecular Brain Research 74 (1-2): 126–34. doi:10.1016/S0169-328X(99)00273-9. PMID 10640683.
• Cousin P, Billotte J, Chaubert P, Shaw P (Jan 2000). "Physical map of 17p13 and the genes adjacent to p53". Genomics 63 (1): 60–8. doi:10.1006/geno.1999.6062. PMID 10662545.
• Franklin A, Kao A, Tapscott S, Unis A (Nov 2001). "NeuroD homologue expression during cortical development in the human brain". Journal of Child Neurology 16 (11): 849–53. doi:10.1177/08830738010160111201. PMID 11732772.
• Westerman BA, Poutsma A, Maruyama K, Schrijnemakers HF, van Wijk IJ, Oudejans CB (Apr 2002). "The proneural genes NEUROD1 and NEUROD2 are expressed during human trophoblast invasion". Mechanisms of Development 113 (1): 85–90. doi:10.1016/S0925-4773(01)00665-7. PMID 11900979.
• Westerman BA, Chhatta A, Poutsma A, van Vegchel T, Oudejans CB (Jan 2004). "NEUROD1 acts in vitro as an upstream regulator of NEUROD2 in trophoblast cells". Biochimica et Biophysica Acta 1676 (1): 96–103. doi:10.1016/j.bbaexp.2003.10.002. PMID 14732494.
• Zill P, Büttner A, Eisenmenger W, Bondy B (Jun 2006). "A possible impact of the neuroD2 transcription factor on the development of drug abusing behavior". Molecular Psychiatry 11 (6): 525–7. doi:10.1038/sj.mp.4001825. PMID 16607387.

External links

• NEUROD2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.