ETV1

Ets variant 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4AVP​, 4BNC​
Identifiers
Symbols	ETV1 ; ER81
External IDs	OMIM: 600541 MGI: 99254 HomoloGene: 3636 GeneCards: ETV1 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • protein binding Cellular component • nucleus Biological process • transcription from RNA polymerase II promoter • axon guidance • muscle organ development • mechanosensory behavior • cell differentiation • positive regulation of transcription from RNA polymerase II promoter • peripheral nervous system neuron development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2115	14009
Ensembl	ENSG00000006468	ENSMUSG00000004151
UniProt	P50549	P41164
RefSeq (mRNA)	NM_001163147	NM_001163154
RefSeq (protein)	NP_001156619	NP_001156626
Location (UCSC)	Chr 7: 13.89 – 13.99 Mb	Chr 12: 38.78 – 38.87 Mb
PubMed search

ETS translocation variant 1 is a protein that in humans is encoded by the ETV1 gene.^[1][2]

References

1. Brown TA, McKnight SL (Dec 1992). "Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins". Genes & Development 6 (12B): 2502–12. doi:10.1101/gad.6.12b.2502. PMID 1340465.
2. "Entrez Gene: ETV1 ets variant gene 1".

Further reading

• Monté D, Coutte L, Baert JL, Angeli I, Stéhelin D, de Launoit Y (Aug 1995). "Molecular characterization of the ets-related human transcription factor ER81". Oncogene 11 (4): 771–9. PMID 7651741.
• Jeon IS, Davis JN, Braun BS, Sublett JE, Roussel MF, Denny CT, Shapiro DN (Mar 1995). "A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1". Oncogene 10 (6): 1229–34. PMID 7700648.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Carrère S, Verger A, Flourens A, Stehelin D, Duterque-Coquillaud M (Jun 1998). "Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains". Oncogene 16 (25): 3261–8. doi:10.1038/sj.onc.1201868. PMID 9681824.
• Coutte L, Monté D, Imai K, Pouilly L, Dewitte F, Vidaud M, Adamski J, Baert JL, de Launoit Y (Nov 1999). "Characterization of the human and mouse ETV1/ER81 transcription factor genes: role of the two alternatively spliced isoforms in the human". Oncogene 18 (46): 6278–86. doi:10.1038/sj.onc.1203020. PMID 10597226.
• Janknecht R (Nov 2001). "Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase 2". The Journal of Biological Chemistry 276 (45): 41856–61. doi:10.1074/jbc.M106630200. PMID 11551945.
• Wu J, Janknecht R (Nov 2002). "Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A". The Journal of Biological Chemistry 277 (45): 42669–79. doi:10.1074/jbc.M205501200. PMID 12213813.
• Janknecht R (Feb 2003). "Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1)". Oncogene 22 (5): 746–55. doi:10.1038/sj.onc.1206185. PMID 12569367.
• Goel A, Janknecht R (Sep 2003). "Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu". Molecular and Cellular Biology 23 (17): 6243–54. doi:10.1128/MCB.23.17.6243-6254.2003. PMC 180970. PMID 12917345.
• Dowdy SC, Mariani A, Janknecht R (Nov 2003). "HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81". The Journal of Biological Chemistry 278 (45): 44377–84. doi:10.1074/jbc.M307202200. PMID 12947087.
• Goel A, Janknecht R (Apr 2004). "Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu". The Journal of Biological Chemistry 279 (15): 14909–16. doi:10.1074/jbc.M400036200. PMID 14747462.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gocke CB, Yu H, Kang J (Feb 2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates". The Journal of Biological Chemistry 280 (6): 5004–12. doi:10.1074/jbc.M411718200. PMID 15561718.

External links

• ETV1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)