Sp4 transcription factor

Sp4 transcription factor
PDB rendering based on 1va1.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1va1​
Identifiers
Symbols	SP4 ; HF1B; SPR-1
External IDs	OMIM: 600540 MGI: 107595 HomoloGene: 2341 GeneCards: SP4 Gene
Gene ontology Molecular function • RNA polymerase II transcription factor activity, sequence-specific DNA binding • DNA binding • transcription coactivator activity • protein binding • metal ion binding Cellular component • nucleus • nucleoplasm • cytoplasm • microtubule cytoskeleton • intercellular bridge Biological process • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • regulation of heart contraction Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6671	20688
Ensembl	ENSG00000105866	ENSMUSG00000025323
UniProt	Q02446	Q62445
RefSeq (mRNA)	NM_003112	NM_001166385
RefSeq (protein)	NP_003103	NP_001159857
Location (UCSC)	Chr 7: 21.43 – 21.51 Mb	Chr 12: 118.23 – 118.3 Mb
PubMed search

Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene.^[1][2]

Interactions

Sp4 transcription factor has been shown to interact with E2F1.^[3]

References

1. Hagen G, Müller S, Beato M, Suske G (Nov 1992). "Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes". Nucleic Acids Research 20 (21): 5519–25. doi:10.1093/nar/20.21.5519. PMC 334381. PMID 1454515.
2. "Entrez Gene: SP4 Sp4 transcription factor".
3. Rotheneder H, Geymayer S, Haidweger E (Nov 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". Journal of Molecular Biology 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. PMID 10547281.

Further reading

• Suske G (Oct 1999). "The Sp-family of transcription factors". Gene 238 (2): 291–300. doi:10.1016/S0378-1119(99)00357-1. PMID 10570957.
• Hagen G, Dennig J, Preiss A, Beato M, Suske G (Oct 1995). "Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3". The Journal of Biological Chemistry 270 (42): 24989–94. doi:10.1074/jbc.270.42.24989. PMID 7559627.
• Kalff-Suske M, Kunz J, Grzeschik KH, Suske G (Apr 1995). "Human Sp4 transcription factor gene (SP4) maps to chromosome 7p15". Genomics 26 (3): 631–3. doi:10.1016/0888-7543(95)80191-N. PMID 7607696.
• Majello B, De Luca P, Hagen G, Suske G, Lania L (Nov 1994). "Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1". Nucleic Acids Research 22 (23): 4914–21. doi:10.1093/nar/22.23.4914. PMC 523756. PMID 7800480.
• Rotheneder H, Geymayer S, Haidweger E (Nov 1999). "Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter". Journal of Molecular Biology 293 (5): 1005–15. doi:10.1006/jmbi.1999.3213. PMID 10547281.
• Nguyên-Trân VT, Kubalak SW, Minamisawa S, Fiset C, Wollert KC, Brown AB, Ruiz-Lozano P, Barrere-Lemaire S, Kondo R, Norman LW, Gourdie RG, Rahme MM, Feld GK, Clark RB, Giles WR, Chien KR (Sep 2000). "A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages". Cell 102 (5): 671–82. doi:10.1016/S0092-8674(00)00089-1. PMID 11007485.
• Lerner LE, Gribanova YE, Ji M, Knox BE, Farber DB (Sep 2001). "Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of multiple response elements". The Journal of Biological Chemistry 276 (37): 34999–5007. doi:10.1074/jbc.M103301200. PMID 11438531.
• Lerner LE, Gribanova YE, Whitaker L, Knox BE, Farber DB (Jul 2002). "The rod cGMP-phosphodiesterase beta-subunit promoter is a specific target for Sp4 and is not activated by other Sp proteins or CRX". The Journal of Biological Chemistry 277 (29): 25877–83. doi:10.1074/jbc.M201407200. PMID 11943774.
• Lee DK, Suh D, Edenberg HJ, Hur MW (Jul 2002). "POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1". The Journal of Biological Chemistry 277 (30): 26761–8. doi:10.1074/jbc.M202078200. PMID 12004059.
• Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (Jun 2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Molecular Vision 8: 196–204. PMID 12107411.
• Davis W, Chen ZJ, Ile KE, Tew KD (Feb 2003). "Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors". Nucleic Acids Research 31 (3): 1097–107. doi:10.1093/nar/gkg192. PMC 149212. PMID 12560508.
• Hong J, Samudio I, Liu S, Abdelrahim M, Safe S (Dec 2004). "Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins". Endocrinology 145 (12): 5774–85. doi:10.1210/en.2004-0686. PMID 15345676.
• Phillips RJ, Tyson-Capper Née Pollard AJ, Bailey J, Robson SC, Europe-Finner GN (Jun 2005). "Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases". The Journal of Clinical Endocrinology and Metabolism 90 (6): 3479–90. doi:10.1210/jc.2004-1962. PMID 15788387.
• Higgins KJ, Liu S, Abdelrahim M, Yoon K, Vanderlaag K, Porter W, Metz RP, Safe S (Jul 2006). "Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins". Endocrinology 147 (7): 3285–95. doi:10.1210/en.2006-0081. PMID 16574784.
• Gao YQ, Danciger M, Ozgul RK, Gribanova Y, Jacobson S, Farber DB (2007). "Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease". Molecular Vision 13: 287–92. PMC 2633482. PMID 17356515.

External links

• Sp4 Transcription Factor at the US National Library of Medicine Medical Subject Headings (MeSH)