MEIS1

Meis homeobox 1
Identifiers
Symbols	MEIS1 ; MGC43380
External IDs	OMIM: 601739 MGI: 104717 HomoloGene: 135741 GeneCards: MEIS1 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • protein binding • protein heterodimerization activity Cellular component • nucleus • transcription factor complex Biological process • angiogenesis • lens morphogenesis in camera-type eye • transcription from RNA polymerase II promoter • locomotory behavior • megakaryocyte development • negative regulation of myeloid cell differentiation • negative regulation of neuron differentiation • positive regulation of transcription from RNA polymerase II promoter • definitive hemopoiesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4211	17268
Ensembl	ENSG00000143995	ENSMUSG00000020160
UniProt	O00470	Q60954
RefSeq (mRNA)	NM_002398	NM_001193271
RefSeq (protein)	NP_002389	NP_001180200
Location (UCSC)	Chr 2: 66.43 – 66.57 Mb	Chr 11: 18.88 – 19.02 Mb
PubMed search

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.^[1][2]

Function

Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.^[2]

Interactions

MEIS1 has been shown to interact with PBX1^[3][4][5] and HOXA9.^[3][6]

References

1. Moskow JJ, Bullrich F, Huebner K, Daar IO, Buchberg AM (Oct 1995). "Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice". Molecular and Cellular Biology 15 (10): 5434–43. PMC 230793. PMID 7565694.
2. "Entrez Gene: MEIS1 Meis homeobox 1".
3. Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology 19 (4): 3051–61. PMC 84099. PMID 10082572.
4. Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology 19 (11): 7577–88. PMC 84774. PMID 10523646.
5. Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology 19 (7): 5134–42. PMC 84356. PMID 10373562.
6. Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology 17 (11): 6448–58. PMC 232497. PMID 9343407.

Further reading

• Allen TD, Zhu YX, Hawley TS, Hawley RG (Oct 2000). "TALE homeoproteins as HOX11-interacting partners in T-cell leukemia". Leukemia & Lymphoma 39 (3-4): 241–56. doi:10.3109/10428190009065824. PMID 11342305.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Steelman S, Moskow JJ, Muzynski K, North C, Druck T, Montgomery JC, Huebner K, Daar IO, Buchberg AM (Feb 1997). "Identification of a conserved family of Meis1-related homeobox genes". Genome Research 7 (2): 142–56. doi:10.1101/gr.7.2.142. PMID 9049632.
• Smith JE, Bollekens JA, Inghirami G, Takeshita K (Jul 1997). "Cloning and mapping of the MEIS1 gene, the human homolog of a murine leukemogenic gene". Genomics 43 (1): 99–103. doi:10.1006/geno.1997.4766. PMID 9226379.
• Shen WF, Montgomery JC, Rozenfeld S, Moskow JJ, Lawrence HJ, Buchberg AM, Largman C (Nov 1997). "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology 17 (11): 6448–58. PMC 232497. PMID 9343407.
• Knoepfler PS, Calvo KR, Chen H, Antonarakis SE, Kamps MP (Dec 1997). "Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1". Proceedings of the National Academy of Sciences of the United States of America 94 (26): 14553–8. doi:10.1073/pnas.94.26.14553. PMC 25052. PMID 9405651.
• "Toward a complete human genome sequence". Genome Research 8 (11): 1097–108. Nov 1998. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Shen WF, Rozenfeld S, Kwong A, Köm ves LG, Lawrence HJ, Largman C (Apr 1999). "HOXA9 forms triple complexes with PBX2 and MEIS1 in myeloid cells". Molecular and Cellular Biology 19 (4): 3051–61. PMC 84099. PMID 10082572.
• Jacobs Y, Schnabel CA, Cleary ML (Jul 1999). "Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity". Molecular and Cellular Biology 19 (7): 5134–42. PMC 84356. PMID 10373562.
• Knoepfler PS, Bergstrom DA, Uetsuki T, Dac-Korytko I, Sun YH, Wright WE, Tapscott SJ, Kamps MP (Sep 1999). "A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1". Nucleic Acids Research 27 (18): 3752–61. doi:10.1093/nar/27.18.3752. PMC 148632. PMID 10471746.
• Shanmugam K, Green NC, Rambaldi I, Saragovi HU, Featherstone MS (Nov 1999). "PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins". Molecular and Cellular Biology 19 (11): 7577–88. PMC 84774. PMID 10523646.
• Spieker N, van Sluis P, Beitsma M, Boon K, van Schaik BD, van Kampen AH, Caron H, Versteeg R (Jan 2001). "The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32". Genomics 71 (2): 214–21. doi:10.1006/geno.2000.6408. PMID 11161815.
• Wang Y, Yin L, Hillgartner FB (Jun 2001). "The homeodomain proteins PBX and MEIS1 are accessory factors that enhance thyroid hormone regulation of the malic enzyme gene in hepatocytes". The Journal of Biological Chemistry 276 (26): 23838–48. doi:10.1074/jbc.M102166200. PMID 11331288.
• Okada Y, Nagai R, Sato T, Matsuura E, Minami T, Morita I, Doi T (Jun 2003). "Homeodomain proteins MEIS1 and PBXs regulate the lineage-specific transcription of the platelet factor 4 gene". Blood 101 (12): 4748–56. doi:10.1182/blood-2002-02-0380. PMID 12609849.
• Zeisig BB, Milne T, García-Cuéllar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK (Jan 2004). "Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization". Molecular and Cellular Biology 24 (2): 617–28. doi:10.1128/MCB.24.2.617-628.2004. PMC 343796. PMID 14701735.
• Pineault N, Abramovich C, Ohta H, Humphries RK (Mar 2004). "Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1". Molecular and Cellular Biology 24 (5): 1907–17. doi:10.1128/MCB.24.5.1907-1917.2004. PMC 350554. PMID 14966272.

External links

• MEIS1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.