NPAS2

Neuronal PAS domain protein 2
Identifiers
Symbols	NPAS2 ; MOP4; PASD4; bHLHe9
External IDs	OMIM: 603347 MGI: 109232 HomoloGene: 1887 GeneCards: NPAS2 Gene
Gene ontology Molecular function • core promoter binding • DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding • metal ion binding • protein dimerization activity • Hsp90 protein binding Cellular component • nucleus • nucleoplasm • transcription factor complex • cytosol Biological process • transcription, DNA-templated • cellular response to DNA damage stimulus • central nervous system development • circadian rhythm • circadian regulation of gene expression • circadian sleep/wake cycle • cellular lipid metabolic process • small molecule metabolic process • locomotor rhythm • positive regulation of DNA repair • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • response to redox state • negative regulation of cell death • regulation of response to DNA damage stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4862	18143
Ensembl	ENSG00000170485	ENSMUSG00000026077
UniProt	Q99743	P97460
RefSeq (mRNA)	NM_002518	NM_008719
RefSeq (protein)	NP_002509	NP_032745
Location (UCSC)	Chr 2: 100.82 – 101 Mb	Chr 1: 39.19 – 39.36 Mb
PubMed search

Neuronal PAS domain-containing protein 2 is a protein that in humans is encoded by the NPAS2 gene.^[1][2]

Function

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain.^[3]

NPAS2 has been shown to be analogous to the function of CLOCK in CLOCK deficient mice.^[4]

Interactions

NPAS2 has been shown to interact with:

• ARNTL,^[5][6]
• EP300,^[7] and
• Retinoic acid receptor alpha.^[5]

References

1. Zhou YD, Barnard M, Tian H, Li X, Ring HZ, Francke U, Shelton J, Richardson J, Russell DW, McKnight SL (Mar 1997). "Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system". Proc Natl Acad Sci USA 94 (2): 713–8. doi:10.1073/pnas.94.2.713. PMC 19579. PMID 9012850.
2. Hogenesch JB, Chan WK, Jackiw VH, Brown RC, Gu YZ, Pray-Grant M, Perdew GH, Bradfield CA (May 1997). "Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway". J Biol Chem 272 (13): 8581–93. doi:10.1074/jbc.272.13.8581. PMID 9079689.
3. "Entrez Gene: NPAS2 neuronal PAS domain protein 2".
4. Debruyne JP (December 2008). "Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system". J. Genet. 87 (5): 437–46. doi:10.1007/s12041-008-0066-7. PMC 2749070. PMID 19147932.
5. McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA (June 2001). "Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock". Cell 105 (7): 877–89. doi:10.1016/S0092-8674(01)00401-9. PMID 11439184.
6. Hogenesch JB, Gu YZ, Jain S, Bradfield CA (May 1998). "The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors". Proc. Natl. Acad. Sci. U.S.A. 95 (10): 5474–9. doi:10.1073/pnas.95.10.5474. PMC 20401. PMID 9576906.
7. Curtis AM, Seo SB, Westgate EJ, Rudic RD, Smyth EM, Chakravarti D, FitzGerald GA, McNamara P (February 2004). "Histone acetyltransferase-dependent chromatin remodeling and the vascular clock". J. Biol. Chem. 279 (8): 7091–7. doi:10.1074/jbc.M311973200. PMID 14645221.

External links

• NPAS2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.