KLF17

Kruppel-like factor 17
PDB rendering based on 2h58.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2H58​
Identifiers
Symbols	KLF17 ; ZNF393; Zfp393
External IDs	OMIM: 609602 MGI: 109202 HomoloGene: 12621 ChEMBL: 1075119 GeneCards: KLF17 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription • sequence-specific DNA binding transcription factor activity • protein binding • transcription regulatory region DNA binding • metal ion binding Cellular component • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • gamete generation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	128209	75753
Ensembl	ENSG00000171872	ENSMUSG00000048626
UniProt	Q5JT82	Q8CFA7
RefSeq (mRNA)	NM_173484	NM_029416
RefSeq (protein)	NP_775755	NP_083692
Location (UCSC)	Chr 1: 44.12 – 44.14 Mb	Chr 4: 117.76 – 117.77 Mb
PubMed search

Krueppel-like factor 17 is a protein that in humans is encoded by the KLF17 gene.^[1][2]

Model organisms

Model organisms have been used in the study of KLF17 function. A conditional knockout mouse line called Klf17^{tm1b(KOMP)Wtsi} was generated at the Wellcome Trust Sanger Institute.^[3] Male and female animals underwent a standardized phenotypic screen^[4] to determine the effects of deletion.^[5][6][7][8] Additional screens performed: - In-depth immunological phenotyping^[9]

Klf17 knockout mouse phenotype

Characteristic	Phenotype
All data available at.[4][9]
Peripheral blood leukocytes 6 Weeks	Normal
Haematology 6 Weeks	Normal
Insulin	Normal
Homozygous viability at P14	Normal
Homozygous Fertility	Normal
Body weight	Normal
Neurological assessment	Normal
Grip strength	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology 16 Weeks	Normal
Peripheral blood leukocytes 16 Weeks	Normal
Heart weight	Normal
Salmonella infection	Normal
Cytotoxic T Cell Function	Normal
Epidermal Immune Composition	Normal
Influenza Challenge	Normal

References

1. van Vliet J, Crofts LA, Quinlan KG, Czolij R, Perkins AC, Crossley M (Apr 2006). "Human KLF17 is a new member of the Sp/KLF family of transcription factors". Genomics 87 (4): 474–82. doi:10.1016/j.ygeno.2005.12.011. PMID 16460907.
2. "Entrez Gene: KLF17 Kruppel-like factor 17".
3. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
4. "International Mouse Phenotyping Consortium".
5. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
6. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
7. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
8. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
9. "Infection and Immunity Immunophenotyping (3i) Consortium".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Yan W, Burns KH, Ma L, Matzuk MM (Oct 2002). "Identification of Zfp393, a germ cell-specific gene encoding a novel zinc finger protein". Mechanisms of Development 118 (1-2): 233–9. doi:10.1016/S0925-4773(02)00258-7. PMID 12351194.

External links

• KLF17 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)