TFAP4

Transcription factor AP-4 (activating enhancer binding protein 4)
Identifiers
Symbols	TFAP4 ; AP-4; bHLHc41
External IDs	OMIM: 600743 MGI: 103239 HomoloGene: 2424 GeneCards: TFAP4 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • transcription coactivator activity • protein binding • protein homodimerization activity • histone deacetylase binding • sequence-specific DNA binding • transcription regulatory region DNA binding • protein heterodimerization activity • E-box binding Cellular component • nucleus • transcriptional repressor complex Biological process • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • protein complex assembly • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • negative regulation of cell proliferation • positive regulation of apoptotic process • negative regulation of DNA binding • negative regulation by host of viral transcription • positive regulation by host of viral transcription • negative regulation of cyclin-dependent protein serine/threonine kinase activity • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell cycle arrest • cellular response to dexamethasone stimulus • positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7023	83383
Ensembl	ENSG00000090447	ENSMUSG00000005718
UniProt	Q01664	Q9JIZ5
RefSeq (mRNA)	NM_003223	NM_031182
RefSeq (protein)	NP_003214	NP_112459
Location (UCSC)	Chr 16: 4.26 – 4.27 Mb	Chr 16: 4.54 – 4.56 Mb
PubMed search

Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.^[1]

Function

Transcription factor AP4 is a member of the basic helix-loop-helix (bHLH) transcription factors, which bind to the E-box sequence in the promoters of their target genes. AP-4 has been shown to act both as a repressor and an activator for different target genes.

References

1. "Entrez Gene: TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)".

Further reading

• Hu YF, Lüscher B, Admon A, et al. (1991). "Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity". Genes Dev. 4 (10): 1741–52. doi:10.1101/gad.4.10.1741. PMID 2123466.
• Mermod N, Williams TJ, Tjian R (1988). "Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro". Nature 332 (6164): 557–61. doi:10.1038/332557a0. PMID 2833704.
• Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB (1994). "Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function". J. Virol. 68 (11): 7188–99. PMC 237158. PMID 7933101.
• Lewis TB, Wood S, Michaelis EK, et al. (1996). "Localization of a gene for a glutamate binding subunit of a NMDA receptor (GRINA) to 8q24". Genomics 32 (1): 131–3. doi:10.1006/geno.1996.0088. PMID 8786101.
• Petersenn S, Rasch AC, Heyens M, Schulte HM (1998). "Structure and regulation of the human growth hormone-releasing hormone receptor gene". Mol. Endocrinol. 12 (2): 233–47. doi:10.1210/me.12.2.233. PMID 9482665.
• King-Jones K, Korge G, Lehmann M (1999). "The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4". J. Mol. Biol. 291 (1): 71–82. doi:10.1006/jmbi.1999.2963. PMID 10438607.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature 432 (7020): 988–94. doi:10.1038/nature03187. PMID 15616553.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

• TFAP4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.