MYT1
| Myelin transcription factor 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | MYT1 ; C20orf36; MTF1; MYTI; NZF2; PLPB1; ZC2HC4A | ||||||||||||
| External IDs | OMIM: 600379 MGI: 1100535 HomoloGene: 3332 GeneCards: MYT1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 4661 | 17932 | |||||||||||
| Ensembl | ENSG00000196132 | ENSMUSG00000010505 | |||||||||||
| UniProt | Q01538 | Q8CFC2 | |||||||||||
| RefSeq (mRNA) | NM_004535 | NM_001171615 | |||||||||||
| RefSeq (protein) | NP_004526 | NP_001165086 | |||||||||||
| Location (UCSC) |
Chr 20: 64.15 – 64.24 Mb |
Chr 2: 181.76 – 181.83 Mb | |||||||||||
| PubMed search | |||||||||||||
Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.[1][2][3]
Function
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system.[3]
Interactions
MYT1 has been shown to interact with PIN1.[4]
References
- ↑ Kim JG, Hudson LD (Dec 1992). "Novel member of the zinc finger superfamily: A C2-HC finger that recognizes a glia-specific gene". Molecular and Cellular Biology 12 (12): 5632–9. doi:10.1128/mcb.12.12.5632. PMC 360502. PMID 1280325.
- ↑ Booher RN, Holman PS, Fattaey A (Aug 1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". The Journal of Biological Chemistry 272 (35): 22300–6. doi:10.1074/jbc.272.35.22300. PMID 9268380.
- 1 2 "Entrez Gene: MYT1 myelin transcription factor 1".
- ↑ Wells NJ, Watanabe N, Tokusumi T, Jiang W, Verdecia MA, Hunter T (Oct 1999). "The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression". Journal of Cell Science 112 (19): 3361–71. PMID 10504341.
Further reading
- Gogate N, Verma L, Zhou JM, Milward E, Rusten R, O'Connor M, Kufta C, Kim J, Hudson L, Dubois-Dalcq M (Aug 1994). "Plasticity in the adult human oligodendrocyte lineage". The Journal of Neuroscience 14 (8): 4571–87. PMID 7519254.
- Armstrong RC, Kim JG, Hudson LD (Aug 1995). "Expression of myelin transcription factor I (MyTI), a "zinc-finger" DNA-binding protein, in developing oligodendrocytes". Glia 14 (4): 303–21. doi:10.1002/glia.440140407. PMID 8530187.
- Liu F, Stanton JJ, Wu Z, Piwnica-Worms H (Feb 1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex". Molecular and Cellular Biology 17 (2): 571–83. doi:10.1128/mcb.17.2.571. PMC 231782. PMID 9001210.
- Kim JG, Armstrong RC, v Agoston D, Robinsky A, Wiese C, Nagle J, Hudson LD (Oct 1997). "Myelin transcription factor 1 (Myt1) of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system". Journal of Neuroscience Research 50 (2): 272–90. doi:10.1002/(SICI)1097-4547(19971015)50:2<272::AID-JNR16>3.0.CO;2-A. PMID 9373037.
- Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
- Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 6 (3): 197–205. doi:10.1093/dnares/6.3.197. PMID 10470851.
- Hirayama A, Oka A, Ito M, Tanaka F, Okoshi Y, Takashima S (Jan 2003). "Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia". Brain Research. Developmental Brain Research 140 (1): 85–92. doi:10.1016/S0165-3806(02)00585-0. PMID 12524179.
- Nielsen JA, Berndt JA, Hudson LD, Armstrong RC (Jan 2004). "Myelin transcription factor 1 (Myt1) modulates the proliferation and differentiation of oligodendrocyte lineage cells". Molecular and Cellular Neurosciences 25 (1): 111–23. doi:10.1016/j.mcn.2003.10.001. PMID 14962745.
- Vana AC, Lucchinetti CF, Le TQ, Armstrong RC (May 2007). "Myelin transcription factor 1 (Myt1) expression in demyelinated lesions of rodent and human CNS". Glia 55 (7): 687–97. doi:10.1002/glia.20492. PMC 2789289. PMID 17330875.
External links
- MYT1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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