CNBP

CCHC-type zinc finger, nucleic acid binding protein
Identifiers
Symbols	CNBP ; CNBP1; DM2; PROMM; RNF163; ZCCHC22; ZNF9
External IDs	OMIM: 116955 MGI: 88431 HomoloGene: 2567 GeneCards: CNBP Gene
Gene ontology Molecular function • single-stranded DNA binding • transcription factor activity, sequence-specific DNA binding • single-stranded RNA binding • protein binding • zinc ion binding • poly(A) RNA binding Cellular component • nucleus • endoplasmic reticulum • cytosol Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • cholesterol biosynthetic process • positive regulation of cell proliferation • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7555	12785
Ensembl	ENSG00000169714	ENSMUSG00000030057
UniProt	P62633	P53996
RefSeq (mRNA)	NM_001127192	NM_001109745
RefSeq (protein)	NP_001120664	NP_001103215
Location (UCSC)	Chr 3: 129.17 – 129.18 Mb	Chr 6: 87.84 – 87.85 Mb
PubMed search

Cellular nucleic acid-binding protein is a protein that in humans is encoded by the CNBP gene.^[1][2][3]

Function

The ZNF9 protein contains 7 zinc finger domains and is believed to function as an RNA-binding protein. A CCTG expansion in intron 1 of the ZNF9 gene results in myotonic dystrophy type 2 (MIM 602668).[supplied by OMIM]^[3]

References

1. Lusis AJ, Rajavashisth TB, Klisak I, Heinzmann C, Mohandas T, Sparkes RS (Oct 1990). "Mapping of the gene for CNBP, a finger protein, to human chromosome 3q13.3-q24". Genomics 8 (2): 411–4. doi:10.1016/0888-7543(90)90303-C. PMID 2249857.
2. Liquori CL, Ricker K, Moseley ML, Jacobsen JF, Kress W, Naylor SL, Day JW, Ranum LP (Aug 2001). "Myotonic dystrophy type 2 caused by a CCTG expansion in intron 1 of ZNF9". Science 293 (5531): 864–7. doi:10.1126/science.1062125. PMID 11486088.
3. "Entrez Gene: CNBP CCHC-type zinc finger, nucleic acid binding protein".

Further reading

• Rajavashisth TB, Taylor AK, Andalibi A, Svenson KL, Lusis AJ (Aug 1989). "Identification of a zinc finger protein that binds to the sterol regulatory element". Science 245 (4918): 640–3. doi:10.1126/science.2562787. PMID 2562787.
• Flink IL, Morkin E (Oct 1995). "Organization of the gene encoding cellular nucleic acid-binding protein". Gene 163 (2): 279–82. doi:10.1016/0378-1119(95)00421-2. PMID 7590281.
• Warden CH, Krisans SK, Purcell-Huynh D, Leete LM, Daluiski A, Diep A, Taylor BA, Lusis AJ (Nov 1994). "Mouse cellular nucleic acid binding proteins: a highly conserved family identified by genetic mapping and sequencing". Genomics 24 (1): 14–9. doi:10.1006/geno.1994.1576. PMID 7896269.
• Ricker K, Grimm T, Koch MC, Schneider C, Kress W, Reimers CD, Schulte-Mattler W, Mueller-Myhsok B, Toyka KV, Mueller CR (Jan 1999). "Linkage of proximal myotonic myopathy to chromosome 3q". Neurology 52 (1): 170–1. doi:10.1212/wnl.52.1.170. PMID 9921867.
• McGrath CF, Buckman JS, Gagliardi TD, Bosche WJ, Coren LV, Gorelick RJ (Aug 2003). "Human cellular nucleic acid-binding protein Zn2+ fingers support replication of human immunodeficiency virus type 1 when they are substituted in the nucleocapsid protein". Journal of Virology 77 (15): 8524–31. doi:10.1128/JVI.77.15.8524-8531.2003. PMC 165261. PMID 12857921.
• Vallo L, Bonifazi E, Borgiani P, Novelli G, Botta A (Feb 2005). "Characterization of a single nucleotide polymorphism in the ZNF9 gene and analysis of association with myotonic dystrophy type II (DM2) in the Italian population". Molecular and Cellular Probes 19 (1): 71–4. doi:10.1016/j.mcp.2004.09.003. PMID 15652222.
• Botta A, Caldarola S, Vallo L, Bonifazi E, Fruci D, Gullotta F, Massa R, Novelli G, Loreni F (Mar 2006). "Effect of the [CCTG]n repeat expansion on ZNF9 expression in myotonic dystrophy type II (DM2)". Biochimica et Biophysica Acta 1762 (3): 329–34. doi:10.1016/j.bbadis.2005.11.004. PMID 16376058.
• Margolis JM, Schoser BG, Moseley ML, Day JW, Ranum LP (Jun 2006). "DM2 intronic expansions: evidence for CCUG accumulation without flanking sequence or effects on ZNF9 mRNA processing or protein expression". Human Molecular Genetics 15 (11): 1808–15. doi:10.1093/hmg/ddl103. PMID 16624843.
• Toth C, Dunham C, Suchowersky O, Parboosingh J, Brownell K (Feb 2007). "Unusual clinical, laboratory, and muscle histopathological findings in a family with myotonic dystrophy type 2". Muscle & Nerve 35 (2): 259–64. doi:10.1002/mus.20685. PMID 17068784.
• Gerbasi VR, Link AJ (Jun 2007). "The myotonic dystrophy type 2 protein ZNF9 is part of an ITAF complex that promotes cap-independent translation". Molecular & Cellular Proteomics 6 (6): 1049–58. doi:10.1074/mcp.M600384-MCP200. PMID 17327219.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• GeneReviews/NCBI/NIH/UW entry on Myotonic Dystrophy Type 2
• ZNF9 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.