POU4F3

POU class 4 homeobox 3
Identifiers
Symbols	POU4F3 ; BRN3C; DFNA15
External IDs	OMIM: 602460 MGI: 102523 HomoloGene: 2023 GeneCards: POU4F3 Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor activity, sequence-specific DNA binding Cellular component • nucleoplasm Biological process • transcription from RNA polymerase II promoter • visual perception • sensory perception of sound • vestibulocochlear nerve development • retinal ganglion cell axon guidance • inner ear morphogenesis • auditory receptor cell differentiation • positive regulation of transcription from RNA polymerase II promoter • axon extension • neuromuscular process controlling balance • neuron apoptotic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5459	18998
Ensembl	ENSG00000091010	ENSMUSG00000024497
UniProt	Q15319	Q63955
RefSeq (mRNA)	NM_002700	NM_138945
RefSeq (protein)	NP_002691	NP_620395
Location (UCSC)	Chr 5: 146.34 – 146.34 Mb	Chr 18: 42.39 – 42.4 Mb
PubMed search

POU domain, class 4, transcription factor 3 is a protein that in humans is encoded by the POU4F3 gene.^[1][2]

References

1. Vahava O, Morell R, Lynch ED, Weiss S, Kagan ME, Ahituv N, Morrow JE, Lee MK, Skvorak AB, Morton CC, Blumenfeld A, Frydman M, Friedman TB, King MC, Avraham KB (Apr 1998). "Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans". Science 279 (5358): 1950–4. doi:10.1126/science.279.5358.1950. PMID 9506947.
2. "Entrez Gene: POU4F3 POU domain, class 4, transcription factor 3".

Further reading

• Nolan LS, Jagutpal SS, Cadge BA, et al. (2007). "Identification and functional analysis of common sequence variants in the DFNA15 gene, Brn-3c.". Gene 400 (1–2): 89–97. doi:10.1016/j.gene.2007.05.023. PMID 17611044.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Clough RL, Sud R, Davis-Silberman N, et al. (2004). "Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity". Biochem. Biophys. Res. Commun. 324 (1): 372–81. doi:10.1016/j.bbrc.2004.09.074. PMID 15465029.
• Weiss S, Gottfried I, Mayrose I, et al. (2003). "The DFNA15 Deafness Mutation Affects POU4F3 Protein Stability, Localization, and Transcriptional Activity". Mol. Cell. Biol. 23 (22): 7957–64. doi:10.1128/MCB.23.22.7957-7964.2003. PMC 262385. PMID 14585957.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Leonard JH, Cook AL, Van Gele M, et al. (2002). "Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma". Int. J. Cancer 101 (2): 103–10. doi:10.1002/ijc.10554. PMID 12209986.
• Erkman L, McEvilly RJ, Luo L, et al. (1996). "Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development". Nature 381 (6583): 603–6. doi:10.1038/381603a0. PMID 8637595.
• Xiang M, Zhou L, Macke JP, et al. (1995). "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons". J. Neurosci. 15 (7 Pt 1): 4762–85. PMID 7623109.

External links

• POU4F3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.