ING4

Inhibitor of growth family, member 4
PDB rendering based on 1wen.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2K1J​, 2M1R​, 2PNX​, 2VNF​, 4AFL​
Identifiers
Symbols	ING4 ; my036; p29ING4
External IDs	OMIM: 608524 MGI: 107307 HomoloGene: 22952 GeneCards: ING4 Gene
Gene ontology Molecular function • transcription coactivator activity • protein binding • zinc ion binding • methylated histone binding Cellular component • histone acetyltransferase complex • nucleus • nucleoplasm Biological process • DNA replication • chromatin organization • protein acetylation • apoptotic process • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • cell cycle arrest • negative regulation of cell proliferation • positive regulation of apoptotic process • histone H3 acetylation • histone H4-K5 acetylation • histone H4-K8 acetylation • histone H4-K12 acetylation • histone H4-K16 acetylation • negative regulation of transcription, DNA-templated • negative regulation of growth Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51147	28019
Ensembl	ENSG00000111653	ENSMUSG00000030330
UniProt	Q9UNL4	Q8C0D7
RefSeq (mRNA)	NM_001127582	NM_133345
RefSeq (protein)	NP_001121054	NP_579923
Location (UCSC)	Chr 12: 6.65 – 6.66 Mb	Chr 6: 125.04 – 125.05 Mb
PubMed search

Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.^[1][2]

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Alternatively spliced transcript variants have been observed, but the biological validity of them has not been determined.^[2]

Interactions

ING4 has been shown to interact with EP300,^[1] RELA^[3] and P53.^[1][4]

References

1. Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (May 2003). "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity". Cancer Res 63 (10): 2373–8. PMID 12750254.
2. "Entrez Gene: ING4 inhibitor of growth family, member 4".
3. Garkavtsev, Igor; Kozin Sergey V; Chernova Olga; Xu Lei; Winkler Frank; Brown Edward; Barnett Gene H; Jain Rakesh K (Mar 2004). "The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis". Nature (England) 428 (6980): 328–32. doi:10.1038/nature02329. PMID 15029197.
4. Tsai, Kuo-Wang; Tseng Hsiao-Chun; Lin Wen-Chang (Oct 2008). "Two wobble-splicing events affect ING4 protein subnuclear localization and degradation". Exp. Cell Res. (United States) 314 (17): 3130–41. doi:10.1016/j.yexcr.2008.08.002. PMID 18775696.

Further reading

• Ozer A, Bruick RK (2006). "Regulation of HIF by prolyl hydroxylases: recruitment of the candidate tumor suppressor protein ING4.". Cell Cycle 4 (9): 1153–6. doi:10.4161/cc.4.9.2040. PMID 16096374.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Garkavtsev I, Kozin SV, Chernova O, et al. (2004). "The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis.". Nature 428 (6980): 328–32. doi:10.1038/nature02329. PMID 15029197.
• Zhang X, Xu LS, Wang ZQ, et al. (2004). "ING4 induces G2/M cell cycle arrest and enhances the chemosensitivity to DNA-damage agents in HepG2 cells.". FEBS Lett. 570 (1-3): 7–12. doi:10.1016/j.febslet.2004.06.010. PMID 15251430.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim S, Chin K, Gray JW, Bishop JM (2004). "A screen for genes that suppress loss of contact inhibition: identification of ING4 as a candidate tumor suppressor gene in human cancer.". Proc. Natl. Acad. Sci. U.S.A. 101 (46): 16251–6. doi:10.1073/pnas.0407158101. PMC 528940. PMID 15528276.
• Zhang X, Wang KS, Wang ZQ, et al. (2005). "Nuclear localization signal of ING4 plays a key role in its binding to p53.". Biochem. Biophys. Res. Commun. 331 (4): 1032–8. doi:10.1016/j.bbrc.2005.04.023. PMID 15882981.
• Ozer A, Wu LC, Bruick RK (2005). "The candidate tumor suppressor ING4 represses activation of the hypoxia inducible factor (HIF).". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7481–6. doi:10.1073/pnas.0502716102. PMC 1140452. PMID 15897452.
• Gunduz M, Nagatsuka H, Demircan K, et al. (2005). "Frequent deletion and down-regulation of ING4, a candidate tumor suppressor gene at 12p13, in head and neck squamous cell carcinomas.". Gene 356: 109–17. doi:10.1016/j.gene.2005.02.014. PMID 15935570.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.". Mol. Cell 23 (4): 607–18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.
• Unoki M, Shen JC, Zheng ZM, Harris CC (2006). "Novel splice variants of ING4 and their possible roles in the regulation of cell growth and motility.". J. Biol. Chem. 281 (45): 34677–86. doi:10.1074/jbc.M606296200. PMID 16973615.
• Raho G, Miranda C, Tamborini E, et al. (2007). "Detection of novel mRNA splice variants of human ING4 tumor suppressor gene.". Oncogene 26 (36): 5247–57. doi:10.1038/sj.onc.1210335. PMID 17325660.
• Zhang X, Lin DH, Jin Y, et al. (2007). "Inhibitor of growth 4 (ING4) is up-regulated by a low K intake and suppresses renal outer medullary K channels (ROMK) by MAPK stimulation.". Proc. Natl. Acad. Sci. U.S.A. 104 (22): 9517–22. doi:10.1073/pnas.0703383104. PMC 1890526. PMID 17517644.

External links

• ING4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.