MXD3

MAX dimerization protein 3
Identifiers
Symbols	MXD3 ; BHLHC13; MAD3; MYX
External IDs	OMIM: 609450 HomoloGene: 32333 GeneCards: MXD3 Gene
Gene ontology Molecular function • DNA binding • protein binding • protein dimerization activity Cellular component • nucleus Biological process • transcription, DNA-templated • negative regulation of transcription, DNA-templated Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83463	17121
Ensembl	ENSG00000213347	ENSMUSG00000021485
UniProt	Q9BW11	Q80US8
RefSeq (mRNA)	NM_001142935	NM_016662
RefSeq (protein)	NP_001136407	NP_057871
Location (UCSC)	Chr 5: 177.3 – 177.31 Mb	Chr 13: 55.33 – 55.33 Mb
PubMed search

MAX dimerization protein 3 is a protein that in humans is encoded by the MXD3 gene located on Chromosome 5.^[1][2]

MXD3 is a basic helix-loop-helix protein belonging to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex.^[2] MXD3 is a transcriptional repressor that is specifically expressed during S phase of the cell cycle. ^[3] The protein is implicated in both normal neural development and in the development of brain cancer. In medulloblastoma cells, MXD3 binds E-box sequences, leading to increased cell proliferation at moderate MXD3 levels but increased cell death and apoptosis at higher expression levels. ^[4]

References

1. Hurlin PJ, Quéva C, Koskinen PJ, Steingrímsson E, Ayer DE, Copeland NG, Jenkins NA, Eisenman RN (November 1995). "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.". EMBO J 14 (22): 5646–59. PMC 394680. PMID 8521822.
2. "Entrez Gene: MXD3 MAX dimerization protein 3".
3. Fox EJ, Wright SC. (February 2003). "The transcriptional repressor gene Mad3 is a novel target for regulation by E2F1.". Biochem J 370 (1): 307–13. doi:10.1042/bj20021583. PMC 1223166. PMID 12444919.
4. Barisone GA, Ngo T, Tran M, Cortes D, Shahi MH, Nguyen TV, Perez-Lanza D, Matayasuwan W, Díaz E. (July 2012). "Role of MXD3 in proliferation of DAOY human medulloblastoma cells.". PLOS ONE 7 (7): e38508. doi:10.1371/journal.pone.0038508. PMID 22808009.