HOXC10

Homeobox C10
Identifiers
Symbols HOXC10 ; HOX3I
External IDs OMIM: 605560 MGI: 96192 HomoloGene: 9680 GeneCards: HOXC10 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 3226 209448
Ensembl ENSG00000180818 ENSMUSG00000022484
UniProt Q9NYD6 P31257
RefSeq (mRNA) NM_017409 NM_010462
RefSeq (protein) NP_059105 NP_034592
Location (UCSC) Chr 12:
53.99 – 53.99 Mb		 Chr 15:
102.97 – 102.97 Mb
PubMed search

Homeobox protein Hox-C10 is a protein that in humans is encoded by the HOXC10 gene.[1][2]

Function

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation.[2]

Pathology

References

  1. ↑ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
  2. 1 2 "Entrez Gene: HOXC10 homeobox C10".
  3. ↑ Ansari KI, Hussain I, Kasiri S, Mandal SS (Feb 2012). "HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4". Journal of Molecular Endocrinology 48 (1): 61–75. doi:10.1530/JME-11-0078. PMID 22143955.
  4. ↑ Pathiraja TN, Nayak SR, Xi Y, Jiang S, Garee JP, Edwards DP, Lee AV, Chen J, Shea MJ, Santen RJ, Gannon F, Kangaspeska S, Jelinek J, Issa JP, Richer JK, Elias A, McIlroy M, Young LS, Davidson NE, Schiff R, Li W, Oesterreich S (Mar 2014). "Epigenetic reprogramming of HOXC10 in endocrine-resistant breast cancer". Science Translational Medicine 6 (229): 229ra41. doi:10.1126/scitranslmed.3008326. PMID 24670685.

Further reading

  • Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852. 
  • Rabin M, Ferguson-Smith A, Hart CP, Ruddle FH (Dec 1986). "Cognate homeo-box loci mapped on homologous human and mouse chromosomes". Proceedings of the National Academy of Sciences of the United States of America 83 (23): 9104–8. doi:10.1073/pnas.83.23.9104. PMC 387083. PMID 2878432. 
  • Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877. 
  • Flagiello D, Gibaud A, Dutrillaux B, Poupon MF, Malfoy B (Oct 1997). "Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines". FEBS Letters 415 (3): 263–7. doi:10.1016/S0014-5793(97)01118-6. PMID 9357979. 
  • de Stanchina E, Gabellini D, Norio P, Giacca M, Peverali FA, Riva S, Falaschi A, Biamonti G (Jun 2000). "Selection of homeotic proteins for binding to a human DNA replication origin". Journal of Molecular Biology 299 (3): 667–80. doi:10.1006/jmbi.2000.3782. PMID 10835276. 
  • Sandrock B, Egly JM (Sep 2001). "A yeast four-hybrid system identifies Cdk-activating kinase as a regulator of the XPD helicase, a subunit of transcription factor IIH". The Journal of Biological Chemistry 276 (38): 35328–33. doi:10.1074/jbc.M105570200. PMID 11445587. 
  • Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506. 
  • Gabellini D, Colaluca IN, Vodermaier HC, Biamonti G, Giacca M, Falaschi A, Riva S, Peverali FA (Jul 2003). "Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression". The EMBO Journal 22 (14): 3715–24. doi:10.1093/emboj/cdg340. PMC 165610. PMID 12853486. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Zhai Y, Kuick R, Nan B, Ota I, Weiss SJ, Trimble CL, Fearon ER, Cho KR (Nov 2007). "Gene expression analysis of preinvasive and invasive cervical squamous cell carcinomas identifies HOXC10 as a key mediator of invasion". Cancer Research 67 (21): 10163–72. doi:10.1158/0008-5472.CAN-07-2056. PMID 17974957. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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