HES5

Hes family bHLH transcription factor 5
Identifiers
Symbols	HES5 ; bHLHb38
External IDs	OMIM: 607348 MGI: 104876 HomoloGene: 7755 GeneCards: HES5 Gene
Gene ontology Molecular function • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • double-stranded DNA binding • transcription factor binding • protein dimerization activity Cellular component • cellular_component • nucleoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • chondrocyte differentiation • transcription, DNA-templated • protein complex assembly • cell adhesion • Notch signaling pathway • smoothened signaling pathway • brain development • positive regulation of cell proliferation • oligodendrocyte development • telencephalon development • glial cell fate commitment • forebrain radial glial cell differentiation • neural tube development • central nervous system myelination • positive regulation of BMP signaling pathway • regulation of myelination • auditory receptor cell differentiation • positive regulation of tyrosine phosphorylation of Stat3 protein • auditory receptor cell fate determination • camera-type eye development • regulation of cell differentiation • negative regulation of neuron differentiation • positive regulation of Notch signaling pathway • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of JAK-STAT cascade • cell maturation • positive regulation of smooth muscle cell proliferation • astrocyte differentiation • negative regulation of astrocyte differentiation • negative regulation of oligodendrocyte differentiation • regulation of neurogenesis • cartilage development • comma-shaped body morphogenesis • S-shaped body morphogenesis • specification of loop of Henle identity • metanephric nephron tubule morphogenesis • neuronal stem cell maintenance • negative regulation of stem cell differentiation • negative regulation of pro-B cell differentiation • negative regulation of forebrain neuron differentiation • negative regulation of inner ear receptor cell differentiation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	388585	15208
Ensembl	ENSG00000197921	ENSMUSG00000048001
UniProt	Q5TA89	P70120
RefSeq (mRNA)	NM_001010926	NM_010419
RefSeq (protein)	NP_001010926	NP_034549
Location (UCSC)	Chr 1: 2.53 – 2.53 Mb	Chr 4: 154.96 – 154.96 Mb
PubMed search

Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.^[1][2]

HES5 regulates brain development process.^[3] HES5 expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia.^[4] Human HES5 gene binds to Notch receptor and expression of HES5 decreases during cartilage differentiation.^[5]

References

1. Takebayashi K, Akazawa C, Nakanishi S, Kageyama R (Feb 1995). "Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element". J Biol Chem 270 (3): 1342–9. doi:10.1074/jbc.270.3.1342. PMID 7836401.
2. "Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)".
3. Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R (November 2004). "Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation". Development 131 (22): 5539–50. doi:10.1242/dev.01436. PMID 15496443.
4. Liu J, Ye F, Chen H, Lü W, Zhou C, Xie X (2007). "Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors". Int. J. Gynecol. Cancer 17 (6): 1293–9. doi:10.1111/j.1525-1438.2007.00930.x. PMID 17388915.
5. Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A (March 2007). "Notch and HES5 are regulated during human cartilage differentiation". Cell Tissue Res. 327 (3): 539–51. doi:10.1007/s00441-006-0307-0. PMID 17093926.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gazit R, Krizhanovsky V, Ben-Arie N (2004). "Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.". Development 131 (4): 903–13. doi:10.1242/dev.00982. PMID 14757642.
• Nakatani T, Mizuhara E, Minaki Y, et al. (2004). "Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system.". J. Biol. Chem. 279 (16): 16356–67. doi:10.1074/jbc.M311740200. PMID 14764602.
• Kamakura S, Oishi K, Yoshimatsu T, et al. (2004). "Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.". Nat. Cell Biol. 6 (6): 547–54. doi:10.1038/ncb1138. PMID 15156153.
• Katoh M, Katoh M (2005). "Identification and characterization of human HES2, HES3, and HES5 genes in silico.". Int. J. Oncol. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753.
• Ohtsuka T, Imayoshi I, Shimojo H, et al. (2006). "Visualization of embryonic neural stem cells using Hes promoters in transgenic mice.". Mol. Cell. Neurosci. 31 (1): 109–22. doi:10.1016/j.mcn.2005.09.006. PMID 16214363.
• Ong CT, Cheng HT, Chang LW, et al. (2006). "Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability.". J. Biol. Chem. 281 (8): 5106–19. doi:10.1074/jbc.M506108200. PMID 16365048.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Karlsson C, Brantsing C, Svensson T, et al. (2007). "Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors.". J. Orthop. Res. 25 (2): 152–63. doi:10.1002/jor.20287. PMID 17072841.
• Karlsson C, Jonsson M, Asp J, et al. (2007). "Notch and HES5 are regulated during human cartilage differentiation.". Cell Tissue Res. 327 (3): 539–51. doi:10.1007/s00441-006-0307-0. PMID 17093926.

External links

• HES5 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.