CEBPG

CCAAT/enhancer binding protein (C/EBP), gamma
Identifiers
Symbols	CEBPG ; GPE1BP; IG/EBP-1
External IDs	OMIM: 138972 MGI: 104982 HomoloGene: 1368 GeneCards: CEBPG Gene
Gene ontology Molecular function • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • DNA binding • double-stranded DNA binding • protein binding • transcription factor binding • sequence-specific DNA binding • protein heterodimerization activity Cellular component • nucleus • nucleoplasm Biological process • liver development • regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • immune response • mRNA metabolic process • B cell differentiation • natural killer cell mediated cytotoxicity • enucleate erythrocyte differentiation • positive regulation of DNA binding • negative regulation of sequence-specific DNA binding transcription factor activity • positive regulation of interferon-gamma biosynthetic process • positive regulation of DNA repair • positive regulation of transcription from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1054	12611
Ensembl	ENSG00000153879	ENSMUSG00000056216
UniProt	P53567	P53568
RefSeq (mRNA)	NM_001252296	NM_009884
RefSeq (protein)	NP_001239225	NP_034014
Location (UCSC)	Chr 19: 33.37 – 33.38 Mb	Chr 7: 35.05 – 35.06 Mb
PubMed search

CCAAT/enhancer-binding protein gamma is a protein that in humans is encoded by the CEBPG gene.^[1][2]

The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements.^[2]

See also

• Ccaat-enhancer-binding proteins

References

1. Williams SC, Cantwell CA, Johnson PF (Oct 1991). "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes Dev 5 (9): 1553–67. doi:10.1101/gad.5.9.1553. PMID 1884998.
2. "Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma".

Further reading

• Nishizawa M, Nagata S (1992). "cDNA clones encoding leucine-zipper proteins which interact with G-CSF gene promoter element 1-binding protein.". FEBS Lett. 299 (1): 36–8. doi:10.1016/0014-5793(92)80094-W. PMID 1371974.
• Thomassin H, Hamel D, Bernier D; et al. (1992). "Molecular cloning of two C/EBP-related proteins that bind to the promoter and the enhancer of the alpha 1-fetoprotein gene. Further analysis of C/EBP beta and C/EBP gamma.". Nucleic Acids Res. 20 (12): 3091–8. doi:10.1093/nar/20.12.3091. PMC 312443. PMID 1377818.
• Nishizawa M, Wakabayashi-Ito N, Nagata S (1991). "Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1.". FEBS Lett. 282 (1): 95–7. doi:10.1016/0014-5793(91)80452-9. PMID 1709121.
• Cooper C, Henderson A, Artandi S; et al. (1996). "Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP family transcriptional activators.". Nucleic Acids Res. 23 (21): 4371–7. doi:10.1093/nar/23.21.4371. PMC 307392. PMID 7501458.
• Davydov IV, Bohmann D, Krammer PH, Li-Weber M (1995). "Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter.". Gene 161 (2): 271–5. doi:10.1016/0378-1119(95)00271-7. PMID 7665092.
• Lundgren M, Larsson C, Femino A; et al. (1994). "Activation of the Ig germ-line gamma 1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site.". J. Immunol. 153 (7): 2983–95. PMID 8089482.
• Martin ML, Lieberman PM, Curran T (1996). "Fos-Jun dimerization promotes interaction of the basic region with TFIIE-34 and TFIIF.". Mol. Cell. Biol. 16 (5): 2110–8. PMC 231198. PMID 8628277.
• Gao H, Parkin S, Johnson PF, Schwartz RC (2002). "C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters.". J. Biol. Chem. 277 (41): 38827–37. doi:10.1074/jbc.M206224200. PMID 12177065.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hattori T, Ohoka N, Inoue Y; et al. (2003). "C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer.". Oncogene 22 (9): 1273–80. doi:10.1038/sj.onc.1206204. PMID 12618752.
• Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays.". Science 300 (5628): 2097–101. doi:10.1126/science.1084648. PMID 12805554.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mullins DN, Crawford EL, Khuder SA; et al. (2006). "CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but not in individuals with bronchogenic carcinoma.". BMC Cancer 5: 141. doi:10.1186/1471-2407-5-141. PMC 1310620. PMID 16255782.

External links

• CEBPG protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.