OSR1

Odd-skipped related transciption factor 1
Identifiers
Symbols	OSR1 ; ODD
External IDs	OMIM: 608891 MGI: 1344424 HomoloGene: 8035 GeneCards: OSR1 Gene
Gene ontology Molecular function • nucleic acid binding • metal ion binding Cellular component • nucleus Biological process • negative regulation of transcription from RNA polymerase II promoter • urogenital system development • ureteric bud development • mesonephros development • chondrocyte differentiation • transcription, DNA-templated • heart development • gonad development • positive regulation of gene expression • cell differentiation • positive regulation of bone mineralization • negative regulation of epithelial cell differentiation • embryonic forelimb morphogenesis • embryonic hindlimb morphogenesis • embryonic skeletal limb joint morphogenesis • middle ear morphogenesis • odontogenesis • embryonic digit morphogenesis • negative regulation of apoptotic process • positive regulation of transcription from RNA polymerase II promoter • intermediate mesoderm development • pronephros development • stem cell differentiation • positive regulation of epithelial cell proliferation • palate development • embryonic skeletal joint morphogenesis • cellular response to retinoic acid • metanephric mesenchyme development • cell proliferation involved in kidney development • metanephric mesenchyme morphogenesis • mesangial cell development • metanephric mesenchymal cell differentiation • posterior mesonephric tubule development • specification of anterior mesonephric tubule identity • specification of posterior mesonephric tubule identity • mesonephric duct morphogenesis • negative regulation of nephron tubule epithelial cell differentiation • renal vesicle progenitor cell differentiation • ureter urothelium development • metanephric epithelium development • metanephric smooth muscle tissue development • metanephric nephron tubule development • metanephric glomerulus vasculature development • metanephric interstitial fibroblast development • pattern specification involved in metanephros development • embryonic skeletal joint development • metanephric cap mesenchymal cell proliferation involved in metanephros development • positive regulation of gastrulation Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	130497	23967
Ensembl	ENSG00000143867	ENSMUSG00000048387
UniProt	Q8TAX0	Q9WVG7
RefSeq (mRNA)	NM_145260	NM_011859
RefSeq (protein)	NP_660303	NP_035989
Location (UCSC)	Chr 2: 19.35 – 19.36 Mb	Chr 12: 9.57 – 9.58 Mb
PubMed search

Protein odd-skipped-related 1 is a transcription factor that in humans is encoded by the OSR1 gene.^[1][2][3] The OSR1 and OSR2 transcription factors participate in the normal development of body parts such as the kidney.^[4]

References

1. Coulter DE, Swaykus EA, Beran-Koehn MA, Goldberg D, Wieschaus E, Schedl P (Nov 1990). "Molecular analysis of odd-skipped, a zinc finger encoding segmentation gene with a novel pair-rule expression pattern". EMBO J 9 (11): 3795–804. PMC 552139. PMID 2120051.
2. Katoh M (Jul 2002). "Molecular cloning and characterization of OSR1 on human chromosome 2p24". Int J Mol Med 10 (2): 221–5. doi:10.3892/ijmm.10.2.221. PMID 12119563.
3. "Entrez Gene: OSR1 odd-skipped related 1 (Drosophila)".
4. Zhang, Z.; Iglesias, D.; Eliopoulos, N.; El Kares, R.; Chu, L.; Romagnani, P.; Goodyer, P. (2011). "A variant OSR1 allele which disturbs OSR1 mRNA expression in renal progenitor cells is associated with reduction of newborn kidney size and function". Human Molecular Genetics 20 (21): 4167–4174. doi:10.1093/hmg/ddr341. PMID 21821672.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Chicago Tribune’s Trine Tsouderos Undermines OSR Antioxidant

See also

OSR2 (gene)

External links

• OSR1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.