DIDO1

Death inducer-obliterator 1
PDB rendering based on 1wem.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2M3H​, 4L7X​
Identifiers
Symbols	DIDO1 ; BYE1; C20orf158; DATF-1; DATF1; DIDO2; DIDO3; DIO-1; DIO1; dJ885L7.8
External IDs	OMIM: 604140 MGI: 1344352 HomoloGene: 34139 GeneCards: DIDO1 Gene
Gene ontology Molecular function • zinc ion binding • poly(A) RNA binding Cellular component • nucleus • cytoplasm • spindle Biological process • transcription, DNA-templated • apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11083	23856
Ensembl	ENSG00000101191	ENSMUSG00000038914
UniProt	Q9BTC0	Q8C9B9
RefSeq (mRNA)	NM_001193369	NM_001291432
RefSeq (protein)	NP_001180298	NP_001278361
Location (UCSC)	Chr 20: 62.88 – 62.94 Mb	Chr 2: 180.66 – 180.71 Mb
PubMed search

Death-inducer obliterator 1 is a protein that in humans is encoded by the DIDO1 gene.^[1][2]

Function

Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms.^[2]

References

1. Garcia-Domingo D, Leonardo E, Grandien A, Martinez P, Albar JP, Izpisua-Belmonte JC, Martinez-A C (Aug 1999). "DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development". Proc Natl Acad Sci U S A 96 (14): 7992–7. doi:10.1073/pnas.96.14.7992. PMC 22175. PMID 10393935.
2. "Entrez Gene: DIDO1 death inducer-obliterator 1".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nagase T, Ishikawa K, Nakajima D; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Gomes I, Sharma TT, Edassery S; et al. (2002). "Novel transcription factors in human CD34 antigen-positive hematopoietic cells.". Blood 100 (1): 107–19. doi:10.1182/blood.V100.1.107. PMID 12070015.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Fu GK, Wang JT, Yang J; et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes.". Genomics 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Fütterer A, Campanero MR, Leonardo E; et al. (2005). "Dido gene expression alterations are implicated in the induction of hematological myeloid neoplasms.". J. Clin. Invest. 115 (9): 2351–62. doi:10.1172/JCI24177. PMC 1190370. PMID 16127461.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Trachana V, van Wely KH, Guerrero AA; et al. (2007). "Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability.". Proc. Natl. Acad. Sci. U.S.A. 104 (8): 2691–6. doi:10.1073/pnas.0611132104. PMC 1815243. PMID 17299043.

External links

• DIDO1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.