TEAD4

TEA domain family member 4
PDB rendering based on 2hzd.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2hzd​
Identifiers
Symbols	TEAD4 ; EFTR-2; RTEF1; TCF13L1; TEF-3; TEF3; TEFR-1; hRTEF-1B
External IDs	OMIM: 601714 MGI: 106907 HomoloGene: 74463 GeneCards: TEAD4 Gene
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding Cellular component • nucleoplasm Biological process • skeletal system development • positive regulation of defense response to virus by host • regulation of transcription from RNA polymerase II promoter • transcription initiation from RNA polymerase II promoter • muscle organ development • gene expression • hippo signaling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7004	21679
Ensembl	ENSG00000197905	ENSMUSG00000030353
UniProt	Q15561	Q62296
RefSeq (mRNA)	NM_003213	NM_001080979
RefSeq (protein)	NP_003204	NP_001074448
Location (UCSC)	Chr 12: 2.96 – 3.04 Mb	Chr 6: 128.22 – 128.3 Mb
PubMed search

Transcriptional enhancer factor TEF-3 is a protein that in humans is encoded by the TEAD4 gene.^[1][2][3]

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.^[4] It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.^[3]

References

1. Jacquemin P, Depetris D, Mattei MG, Martial JA, Davidson I (Mar 1999). "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127–9. doi:10.1006/geno.1998.5628. PMID 9889009.
2. Stewart AF, Richard CW 3rd, Suzow J, Stephan D, Weremowicz S, Morton CC, Adra CN (Feb 1997). "Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family". Genomics 37 (1): 68–76. doi:10.1006/geno.1996.0522. PMID 8921372.
3. "Entrez Gene: TEAD4 TEA domain family member 4".
4. Bürglin, TR (Jul 1991). "The TEA domain: a novel, highly conserved DNA-binding motif". Cell 66 (1): 11–12. doi:10.1016/0092-8674(91)90132-I. PMID 2070413.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Hsu DK, Guo Y, Alberts GF, et al. (1996). "Identification of a murine TEF-1-related gene expressed after mitogenic stimulation of quiescent fibroblasts and during myogenic differentiation". J. Biol. Chem. 271 (23): 13786–95. doi:10.1074/jbc.271.23.13786. PMID 8662936.
• Jacquemin P, Hwang JJ, Martial JA, et al. (1996). "A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain". J. Biol. Chem. 271 (36): 21775–85. doi:10.1074/jbc.271.36.21775. PMID 8702974.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Vaudin P, Delanoue R, Davidson I, et al. (1999). "TONDU (TDU), a novel human protein related to the product of vestigial (vg) gene of Drosophila melanogaster interacts with vertebrate TEF factors and substitutes for Vg function in wing formation". Development 126 (21): 4807–16. PMID 10518497.
• Vassilev A, Kaneko KJ, Shu H, et al. (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm". Genes Dev. 15 (10): 1229–41. doi:10.1101/gad.888601. PMC 313800. PMID 11358867.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Chen HH, Baty CJ, Maeda T, et al. (2005). "Transcription enhancer factor-1-related factor-transgenic mice develop cardiac conduction defects associated with altered connexin phosphorylation". Circulation 110 (19): 2980–7. doi:10.1161/01.CIR.0000146902.84099.26. PMID 15520314.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Appukuttan B, McFarland TJ, Davies MH, et al. (2007). "Identification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina". Invest. Ophthalmol. Vis. Sci. 48 (8): 3775–82. doi:10.1167/iovs.06-1172. PMID 17652751.

External links

• TEAD4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)