ZNF300

Zinc finger protein 300
Identifiers
Symbols	ZNF300 ; DKFZp686B24204
External IDs	OMIM: 612429 MGI: 3045326 HomoloGene: 56531 GeneCards: ZNF300 Gene
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding • metal ion binding Cellular component • nucleus Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	91975	245368
Ensembl	ENSG00000145908	ENSMUSG00000031079
UniProt	Q96RE9	A2AE21
RefSeq (mRNA)	NM_001172831	NM_183185.3
RefSeq (protein)	NP_001166302	NP_899008.2
Location (UCSC)	Chr 5: 150.89 – 150.9 Mb	Chr X: 20.66 – 20.67 Mb
PubMed search

Zinc finger protein 300 is a protein that in humans is encoded by the ZNF300 gene.^[1][2] The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and a likely transcription factor.

Clinical relevance

It is associated with Crohn's disease.^[3]

References

1. Gou D, Wang J, Gao L, Sun Y, Peng X, Huang J, Li W (January 2004). "Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300". Biochim. Biophys. Acta 1676 (2): 203–9. doi:10.1016/j.bbaexp.2003.11.011. PMID 14746915.
2. "Entrez Gene: zinc finger protein 300".
3. Prescott NJ, Dominy KM, Kubo M, Lewis CM, Fisher SA, Redon R, Huang N, Stranger BE, Blaszczyk K, Hudspith B, Parkes G, Hosono N, Yamazaki K, Onnie CM, Forbes A, Dermitzakis ET, Nakamura Y, Mansfield JC, Sanderson J, Hurles ME, Roberts RG, Mathew CG (May 2010). "Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease". Hum. Mol. Genet. 19 (9): 1828–39. doi:10.1093/hmg/ddq041. PMC 2850616. PMID 20106866.

Further reading

• Feng T, Zhu X (2010). "Genome-wide searching of rare genetic variants in WTCCC data.". Hum. Genet. 128 (3): 269–80. doi:10.1007/s00439-010-0849-9. PMC 2922446. PMID 20549515.
• Qiu H, Xue L, Gao L, et al. (2008). "Identification of the DNA binding element of the human ZNF300 protein.". Cell. Mol. Biol. Lett. 13 (3): 391–403. doi:10.2478/s11658-008-0005-x. PMID 18350257.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Xu JH, Wang T, Wang XG, et al. (2010). "PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60.". Leuk. Res. 34 (12): 1636–46. doi:10.1016/j.leukres.2010.04.009. PMID 20471086.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Xue L, Qiu H, Ma J, et al. (2010). "ZNF300, a recently identified human transcription factor, activates the human IL-2Rβ promoter through the overlapping ZNF300/EGR1 binding site.". Cell. Mol. Biol. Lett. 15 (4): 530–40. doi:10.2478/s11658-010-0025-1. PMID 20585888.
• Oh JH, Yang JO, Hahn Y, et al. (2005). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Cao Y, Li JX, Ji CN, et al. (2007). "Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis.". DNA Seq. 18 (4): 312–5. doi:10.1080/10425170701243393. PMID 17541838.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• "Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.". Nature 447 (7145): 661–78. 2007. doi:10.1038/nature05911. PMC 2719288. PMID 17554300.