CSDA (gene)

Y box binding protein 3
PDB rendering based on 1h95.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1h95​
Identifiers
Symbols	YBX3 ; CSDA; CSDA1; DBPA; ZONAB
External IDs	OMIM: 603437 MGI: 2137670 HomoloGene: 2708 GeneCards: YBX3 Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • double-stranded DNA binding • single-stranded DNA binding • transcription factor activity, sequence-specific DNA binding • transcription corepressor activity • mRNA 3'-UTR binding • Rho GTPase binding • poly(A) RNA binding Cellular component • nucleus • cytoplasm • polysome • bicellular tight junction • perinuclear region of cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • in utero embryonic development • transcription, DNA-templated • spermatogenesis • male gonad development • response to cold • fertilization • positive regulation of organ growth • negative regulation of skeletal muscle tissue development • negative regulation of necroptotic process • 3'-UTR-mediated mRNA stabilization • cellular response to tumor necrosis factor • cellular hyperosmotic response • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • positive regulation of cytoplasmic translation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8531	56449
Ensembl	ENSG00000060138	ENSMUSG00000030189
UniProt	P16989	Q9JKB3
RefSeq (mRNA)	NM_001145426	NM_011733
RefSeq (protein)	NP_001138898	NP_035863
Location (UCSC)	Chr 12: 10.7 – 10.72 Mb	Chr 6: 131.36 – 131.39 Mb
PubMed search

DNA-binding protein A is a protein that in humans is encoded by the CSDA gene.^[1][2][3]

References

1. Sakura H, Maekawa T, Imamoto F, Yasuda K, Ishii S (Jun 1989). "Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology". Gene 73 (2): 499–507. doi:10.1016/0378-1119(88)90514-8. PMID 2977358.
2. Coles LS, Diamond P, Occhiodoro F, Vadas MA, Shannon MF (Sep 1996). "Cold shock domain proteins repress transcription from the GM-CSF promoter". Nucleic Acids Res 24 (12): 2311–7. doi:10.1093/nar/24.12.2311. PMC 145951. PMID 8710501.
3. "Entrez Gene: CSDA cold shock domain protein A".

Further reading

• Lloberas J, Soler C, Celada A (1998). "Repression mechanisms of the I-A beta gene of the major histocompatibility complex.". Immunobiology 198 (1-3): 249–63. doi:10.1016/s0171-2985(97)80045-9. PMID 9442396.
• Kudo S, Mattei MG, Fukuda M (1995). "Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain.". Eur. J. Biochem. 231 (1): 72–82. doi:10.1111/j.1432-1033.1995.tb20672.x. PMID 7628487.
• Funke B, Zuleger B, Benavente R; et al. (1996). "The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins.". Nucleic Acids Res. 24 (19): 3821–8. doi:10.1093/nar/24.19.3821. PMC 146158. PMID 8871564.
• Weinmann AS, Yan PS, Oberley MJ; et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis.". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMC 155318. PMID 11799066.
• Hayashi J, Kajino K, Umeda T; et al. (2003). "Somatic mutation and SNP in the promoter of dbpA and human hepatocarcinogenesis.". Int. J. Oncol. 21 (4): 847–50. doi:10.3892/ijo.21.4.847. PMID 12239625.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Coles LS, Bartley MA, Bert A; et al. (2004). "A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA. Potential role in mRNA stabilization.". Eur. J. Biochem. 271 (3): 648–60. doi:10.1111/j.1432-1033.2003.03968.x. PMID 14728692.
• Bouwmeester T, Bauch A, Ruffner H; et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Frankel P, Aronheim A, Kavanagh E; et al. (2005). "RalA interacts with ZONAB in a cell density-dependent manner and regulates its transcriptional activity.". EMBO J. 24 (1): 54–62. doi:10.1038/sj.emboj.7600497. PMC 544910. PMID 15592429.
• Tao WA, Wollscheid B, O'Brien R; et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry.". Nat. Methods 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Sourisseau T, Georgiadis A, Tsapara A; et al. (2006). "Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA.". Mol. Cell. Biol. 26 (6): 2387–98. doi:10.1128/MCB.26.6.2387-2398.2006. PMC 1430269. PMID 16508013.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

External links

• CSDA protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.